牙源性始基瘤4例临床病理学观察  

Clinical and pathological observation of 4 cases of odontogenic primordial tumors

作　　者：张磊[1] 李慧玲 夏舒 帕克扎提·色依提 陈盛[1] 杨艳[1] 叶传进 泥艳红[3] 黄晓峰[1] ZHANG Lei;LI Huiling;XIA Shu;PAKEZHATI·Seyiti;CHEN Sheng;YANG Yan;YE Chuanjin;NI Yanhong;HUANG Xiaofeng(Department of Oral Pathology,2Department of Dentomaxillofacial Radiology,3Central Laboratory,Nanjing Stomatological Hospital,Affiliated Hospital of Medical School,Research Institute of Stomatology,Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属口腔医院/南京市口腔医院/南京大学口腔医学研究所口腔病理科,南京210008 [2]南京大学医学院附属口腔医院/南京市口腔医院/南京大学口腔医学研究所口腔颌面医学影像科,南京210008 [3]南京大学医学院附属口腔医院/南京市口腔医院/南京大学口腔医学研究所中心实验室,南京210008

出　　处：《临床与实验病理学杂志》2024年第7期705-709,共5页Chinese Journal of Clinical and Experimental Pathology

基　　金：国家自然科学基金(82173159);南京大学医学院附属口腔医院“3456”骨干人才资助项目(222E309)。

摘　　要：目的 探讨牙源性始基瘤(primordial odontogenic tumour, POT)的临床病理学特征、诊断和鉴别诊断。方法 收集4例颌骨POT的临床资料,采用影像学检查、HE和免疫组化EnVision两步法染色,分析其临床病理特征并复习相关文献。结果 4例患者发病年龄5~21岁;男女性各2例;发病部位于上、下颌骨各2例。临床表现为缓慢生长的无痛性肿块,切面呈灰黄、灰白色,周围多与1枚未萌牙牙冠相关。肿瘤由黏液样背景中散在疏松梭形或星形细胞组成,周边可见单层立方、柱状上皮被覆,部分区域可见乳头状反褶内陷,2例可见钙化。结论 POT是罕见的良性牙源性混合性肿瘤,好发于儿童和青少年。掌握其特征性的组织学表现可作出正确诊断,行完整切除者预后良好。Purpose To investigate the clinicopathological features,diagnosis and differential diagnosis of the primordial odontogenic tumour(POT).Methods Clinical data of 4 cases of jawbone POT were collected.Imaging examination,HE,and immunohistochemical EnVision two-step staining was used to analyze their clinical and pathological characteristics,and relevant literatures were reviewed.Results The age arranged from 5 years to 21 years.2 cases were male and 2 case were female.There were 2 cases in maxilla and 2 cases in mandible.The clinical presentation was a slow growing painless mass.Cut surface of the tumor was appeared grayish yellow and grayish white,the tumor involved the crown of an unerupted tooth.The tumour consisted of a proliferation of spindled and stellate cells in myxoid stroma.Surfaced by cuboidal to columnar epithelium forming papillary structures and invaginations.Calcification was observed in 2 cases.Conclusion POT is a rare benign mixed odontogenic tumor that is more common in children and adolescents.Mastering its characteristic histological morphology can make a correct diagnosis.Local complete resection of the tumor has a good prognosis.

关 键 词：牙源性肿瘤 牙源性始基瘤 病理学特征 免疫表型 预后 

分 类 号：R739.82[医药卫生—肿瘤]