上皮细胞黏附分子与肺癌、乳腺癌及部分消化系统肿瘤关系的研究进展  

Research advances in the association of epithelial cell adhesion molecule with lung cancer,breast cancer,and some digestive system tumors

作　　者：崔佳丽 王清[2] CUI Jiali;WANG Qing(Department of Clinical Laboratory,Zibo Municipal Hospital,Zibo 255400,China)

机构地区：[1]淄博市市立医院检验科,山东淄博255400 [2]青岛大学附属医院检验科

出　　处：《精准医学杂志》2024年第4期367-370,共4页Journal of Precision Medicine

基　　金：山东省重点研发计划项目(GG201809180014)。

摘　　要：上皮细胞黏附分子(EpCAM)最早在结肠癌细胞中被发现,其可参与调节细胞的黏附、增殖、分化、迁移及信号转导等过程。正常情况下,EpCAM仅表达于正常上皮细胞,然而研究发现,其在人类上皮细胞源性恶性肿瘤中存在且高表达。EpCAM参与肿瘤进展的多个环节,其在肿瘤中独特的表达模式也使其成为最重要的肿瘤生物标志物之一。本文综述了近年来EpCAM作为肿瘤生物标志物的研究进展,以及其在肺癌、乳腺癌和部分消化系统肿瘤治疗中的潜在应用,揭示了EpCAM在肿瘤发展中的重要作用,为其作为治疗靶点提供了科学依据。Epithelial cell adhesion molecule(EpCAM)was first identified in colon cancer cells and is involved in the regulation of cell adhesion,proliferation,differentiation,migration,and signal transduction.Normally,EpCAM is only expressed in normal epithelial cells,but studies have shown that it is present and highly expressed in human epithelial cell-derived malignant tumors.EpCAM is involved in multiple links of tumor progression,and its unique expression pattern in tumor has also made it one of the most important tumor biomarkers.This article reviews the research advances in EpCAM as a tumor biomarker in recent years and its potential application in the treatment of lung cancer,breast cancer,and some digestive system tumors.These studies reveal the important role of EpCAM in tumor progression and provide a scientific basis for its potential as a therapeutic target.

关 键 词：上皮细胞黏附分子 肺肿瘤 乳腺肿瘤 结肠肿瘤 胃肿瘤 肝肿瘤 生物标记 肿瘤 综述 

分 类 号：R73[医药卫生—肿瘤] R392.11[医药卫生—临床医学]