单针与双针微波消融活体猪肺范围  

Ablation ranges of single and double needle microwave ablation of pig lung in vivo

作　　者：寇娜 罗富良 李红丽 滕俊 赵孟菲 江荣华 赵梦媛 王洪武 KOU Na;LUO Fuliang;LI Hongli;TENG Jun;ZHAO Mengfei;JIANG Ronghua;ZHAO Mengyuan;WANG Hongwu(Department of Respiratory,Beijing University of Chinese Medicine,Beijing 100700,China;Department of Radiology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Hygea Medical Technology Co.Ltd,Beijing 100089,China)

机构地区：[1]北京中医药大学东直门医院呼吸科,北京100700 [2]北京中医药大学东直门医院放射科,北京100700 [3]海杰亚(北京)医疗器械有限公司,北京100089

出　　处：《中国介入影像与治疗学》2024年第8期491-494,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：消融联合中医药治疗肺癌的研究(HX-DZM-202309)。

摘　　要：目的对比单针与双针微波消融(MWA)用于活体猪肺所获消融范围的差异。方法对5只健康巴马小型猪双肺分别行单针(单针组)及平行双针MWA(双针组);以不良事件通用术语评价标准(CTCAE)判断MWA过程中的不良事件;基于MWA后即刻CT所见测算消融灶长径(D1CT)、短径(D2CT)、纵径(D3CT)及体积(V),基于标本测算消融灶D1s、D2s及球形度,并进行组间比较。结果在体对活体猪肺进行消融后,单针组消融灶D1CT、D2CT、D3CT及V,以及D1S、D2S及球形度均显著小于双针组(P均<0.01)。单针组1只(1/5,20.00%)发生轻度气胸(CTCAE 1级);双针组1只(1/5,20.00%)发生轻度气胸及肺内出血(均为CTCAE 1级);未见其他不良反应。结论相比单针MWA,双针MWA用于活体猪肺消融范围更大、所获消融灶更接近球体。Objective To compare ablation ranges of single and double needle microwave ablation(MWA)of pig lung in vivo.Methods Five healthy Bama miniature pigs were enrolled.Single needle(single needle group)and parallel double needle MWA(double needle group)were performed successively on bilateral lungs,respectively.Adverse event during MWA was evaluated according to common terminology criteria for adverse events(CTCAE).The long diameter(D1CT),short diameter(D2CT),longitudinal diameter(D3CT)and volume(V)of ablation foci were measured and calculated based on CT images immediately after MWA,whereas D1s,D2s and sphericity of ablation foci were also obtained based on specimen and compared between groups.Results D1CT,D2CT,D3CT and V,as well as D1S,D2S and sphericity of ablation foci in single needle group were all significantly smaller than those in double needle group(all P<0.01).Mild pneumothorax(CTCAE grade 1)was found in 1 pig(1/5,20.00%)in single needle group,while mild pneumothorax and pulmonary hemorrhage(both CTCAE grade 1)occurred in 1 pig(1/5,20.00%)in double needle group.No other adverse event was observed.Conclusion Compared with single needle MWA,double needle MWA of pig lung in vivo resulted larger ablation range and more spherically shaped ablation foci.

关 键 词：消融技术 动物实验 肺 猪 

分 类 号：R-332[医药卫生] R815