分析NSCLC患者血清学指标与OSAS之间的相关性  

Analyze the Correlation between Serological Indexes and OSAS in Patients with NSCLC

作　　者：原改兰 罗少亚 张兵兵 YUAN Gai-lan;LUO Shao-ya;ZHANG Bing-bing(Department of Respiratory and Critical Care Medicine,The Seventh People's Hospital of Zhengzhou,Zhengzhou 450000,Henan Province,China)

机构地区：[1]郑州市第七人民医院呼吸与危重症医学科,河南郑州450000

出　　处：《罕少疾病杂志》2024年第8期45-46,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨非小细胞肺癌(NSCLC)血清学指标与阻塞性睡眠呼吸暂停综合征(OSAS)之间的相关性。方法回顾性分析郑州市第七人民医院2020年10月至2022年10月收治的85例NSCLC患者的临床资料,按照患者是否伴有OSAS将患者分为肺癌组与合并OSAS组,例数分别为45例、40例。另对同期在郑州市第七人民医院进行诊治的50例OSAS患者设置为参照一组,将50例健康体检者设为参照二组。检测研究对象血清学指标进行检测并比较,对肺癌患者血清学各项指标和呼吸暂停通气指数(AHI)、睡眠呼吸暂停临床评分(SACS)评分、细胞间黏附因子-1(ICAM-1)之间的关系采用相关性软件进行分析。结果与参照一组、参照二组、肺癌组患者相比,合并OSAS组患者血清NLRP3炎症小体、缺氧诱导因子-1α(HIF-1α)、血管内皮生长因子(VEGF)水平呈明显上升趋势(均P<0.05);肺癌患者病灶NLRP3、HIF-1α、VEG指标水平随着与AHI、SACS评分、ICAM-1指标的水平呈现为正相关关系(均P<0.05)。结论OSAS与NSCLC的发生与病情的发生和发展之间有着密不可分的关系,其中低氧、炎症反应,以及应激反应为主要的致病原因,临床降低NSCLC的发生率可通过的途径有减轻OSAS患者的炎症、应激反应。Objective To investigate the correlation between the serological parameters of non-small cell lung cancer(NSCLC)and obstructive sleep apnea syndrome(OSAS).Methods The clinical data of 85 NSCLC patients admitted from October 2020 to October 2022 were analyzed,and the patients were divided into lung cancer group and combined OSAS group according to whether the patients had OSAS:45 cases and 40 cases,respectively.In addition,50 cases of OSAS patients treated in the Seventh People's Hospital of Zhengzhou during the same period were set as the reference group,and 50 cases of health examination were set as the reference group.The serological indexes of the study subjects were tested and compared,and the relationship between the serological indicators of lung cancer patients,apnea ventilation index(AHI),sleep apnea clinical score(SACS)score,and cell-cell adhesion factor-1(ICAM-1)were analyzed by correlation software.Results Compared with the patients in the reference group one,reference group two,and lung cancer group,the serum levels of NLRP3 inflammasome,hypoxia inducible factor-1α(HIF-1α),and vascular endothelial growth factor(VEGF)in patients with OSAS showed a significant upward trend(all P<0.05);The levels of NLRP3,HIF-1α,and VEG markers in lung cancer patients showed a positive correlation with AHI,SACS scores,and ICAM-1 markers(all P<0.05).Conclusion The occurrence of OSAS and NSCLC has an inseparable relationship between the occurrence and the occurrence and development of the disease,in which hypoxia,inflammation,and stress response are the main pathogenic causes,and the clinical incidence of NSCLC can be reduced through the way to reduce the inflammation and stress response of OSAS patients.

关 键 词：阻塞性睡眠呼吸暂停综合征 非小细胞肺癌 发病 病情进展 关系 

分 类 号：R734.2[医药卫生—肿瘤]