改良MINE方案治疗侵袭性NK细胞白血病和T细胞淋巴瘤继发噬血细胞综合征3例并文献复习  

Hemophagocytic syndrome secondary to invasive NK cell leukemia and T-cell lymphoma treated with the modified MINE protocol:report of three cases and literature review

作　　者：吴迪 李淼静 李瑶 逯彤霞 付璐瑶 贺鹏程[1] Wu Di;Li Miaojing;Li Yao;Lu Tongxia;Fu Luyao;He Pengcheng(Department of Hematology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Department of Hematology and Oncology,Nuclear Industry 417 Hospital,Xi'an 710600,China)

机构地区：[1]西安交通大学第一附属医院血液内科,西安710061 [2]核工业四一七医院血液肿瘤科,西安710600

出　　处：《中华血液学杂志》2024年第6期599-601,共3页Chinese Journal of Hematology

基　　金：陕西省重点研发计划项目资助(2022SF-008)。

摘　　要：淋巴瘤相关噬血细胞综合征病情凶险,进展迅速,特别在NK/T细胞淋巴瘤多见。MINE方案为侵袭性非霍奇金淋巴瘤挽救性治疗方案。西安交通大学第一附属医院应用改良MINE方案治疗3例继发于侵袭性NK细胞白血病和T细胞淋巴瘤的噬血细胞综合征患者,初步显示该方案对NK/T细胞淋巴瘤的疗效以及对继发噬血细胞综合征炎症状态的控制和良好的耐受性。Lymphoma-associated hemophagocytic syndrome is aggressive with rapid progression,particularly in NK/T cell lymphoma.The MINE regimen is a salvage treatment for aggressive non-Hodgkin lymphoma.In our center,the modified MINE regimen was applied to treat three patients with hemophagocytic syndrome secondary to aggressive NK cell leukemia and T-cell lymphoma.The modified MINE regimen showed good efficacy against NK/T cell lymphoma,control of the inflammatory state of secondary hemophagocytic syndrome,and good tolerability.

关 键 词：噬血细胞综合征 NK/T细胞淋巴瘤 MINE方案 侵袭性NK细胞白血病 炎症状态 挽救性治疗 侵袭性非霍奇金淋巴瘤 第一附属医院 

分 类 号：R733.7[医药卫生—肿瘤] R733.1[医药卫生—临床医学]