益中条达方治疗肝郁脾虚型慢性缺血性结肠炎临床研究  

Clinical Study on Yizhong Tiaoda Prescription for Chronic Ischemic Colitis of Liver Constraint and Spleen Deficiency Type

作　　者：朱静怡 蔡嘉惠 姚民武 ZHU Jingyi;CAI Jiahui;YAO Minwu(Guangzhou University of Chinese Medicine,Guangzhou Guangdong 510405,China;Guangdong Integrated Traditional Chinese and Western Medicine Hospital,Foshan Guangdong 528200,China)

机构地区：[1]广州中医药大学,广东广州510405 [2]广东省中西医结合医院,广东佛山528200

出　　处：《新中医》2024年第15期77-81,共5页New Chinese Medicine

摘　　要：目的:观察益中条达方联合常规西药治疗肝郁脾虚型慢性缺血性结肠炎(IC)的临床疗效。方法:选取肝郁脾虚型慢性IC患者72例,按随机数字表法分为试验组和对照组各36例。对照组予常规西药治疗,试验组在对照组基础上予益中条达方口服,2组疗程均为2周。比较2组治疗前后主要症状积分、白细胞计数(WBC)、血红蛋白(Hb)、C-反应蛋白(CRP)水平、肠镜下肠黏膜病变严重程度分级。结果:治疗后,2组腹痛程度、腹泻次数、便血时间评分及主要症状总积分较治疗前降低(P<0.05),且试验组各项评分低于对照组(P<0.05)。治疗后,2组WBC、CRP水平较治疗前降低,Hb水平较治疗前升高(P<0.05);且试验组WBC、CRP水平低于对照组,Hb水平高于对照组(P<0.05)。治疗后,2组肠镜下肠黏膜病变严重程度分级均较治疗前改善(P<0.05),且试验组肠镜下肠黏膜病变严重程度分级优于对照组(P<0.05)。结论:益中条达方联合常规西药治疗肝郁脾虚型慢性IC患者的临床疗效较好,能有效缓解患者临床症状,降低炎症反应,改善肠黏膜病变情况。Objective:To observe the clinical effect of Yizhong Tiaoda Prescription combined with conventional western medicine on chronic ischemic colitis(IC)of liver constraint and spleen deficiency type.Methods:A total of 72 cases of patients with chronic IC of liver constraint and spleen deficiency type were selected and divided into the trial group and the control group by random number table method,with 36 cases in each group.The control group was treated with conventional western medicine,and the trial group was given oral administration with Yizhong Tiaoda Prescription.Both groups were treated for two weeks.The main symptom scores,levels of white blood cell count(WBC),hemoglobin(Hb),C-reactive protein(CRP),and severity grading of intestinal mucosal lesions under colonoscopy were compared between the two groups before and after treatment.Results:After treatment,the scores of abdominal pain degree,frequency of diarrhea,and rectal bleeding time,as well as the total scores of main symptoms in the two groups were decreased when compared with those before treatment(P<0.05),and each score in the trial group was lower than that in the control group (P<0.05). After treatment,the levelsof WBC and CRP in the two groups were reduced when compared with those before treatment, and Hblevels were increased (P<0.05);the levels of WBC and CRP in the trial group were lower than those in thecontrol group, and Hb level in the trial group was higher than that in the control group (P<0.05). Aftertreatment, the severity grading of intestinal mucosal lesions under colonoscopy in the two groups wasimproved when compared with that before treatment (P<0.05), and the severity grading of intestinalmucosal lesions under colonoscopy in the trial group was better than that in the control group (P<0.05).Conclusion: Yizhong Tiaoda Prescription combined with conventional western medicine has good clinicaleffects on chronic IC of liver constraint and spleen deficiency type, which can effectively relieve clinicalsymptoms of patients,reduce inflammatory r

关 键 词：慢性缺血性结肠炎 益中条达方 肝郁脾虚证 白细胞计数 血红蛋白 C-反应蛋白 肠镜下肠黏膜病变严重程度分级 

分 类 号：R574.62[医药卫生—消化系统]