经直肠剪切波弹性成像联合ACP、FPSA/TPSA预测前列腺癌根治术后生化复发  

The Value of Transrectal Shear Wave Elastography Parameters Combined with Serum ACP and FPSA/TPSA in Predicting Biochemical Recurrence After Radical Prostatectomy

作　　者：江军波 陈绍光 孙尧荣 陈浠溪 Jiang Junbo;Chen Shaoguang;Sun Yaorong;Chen Xixi(Department of Ultrasound,Taizhou Integrated Traditional Chinese and Western Medicine Hospital,Taizhou,Zhejiang 317523,China;Department of Ultrasound,Wenling Traditional Chinese Medicine Hospital,Wenling,Zhejiang 317500,China;Department of Urology,Taizhou Integrated Traditional Chinese and Western Medicine Hospital,Taizhou,Zhejiang 317523,China)

机构地区：[1]台州市中西医结合医院超声科,浙江省台州市317523 [2]温岭市中医院超声科,浙江省温岭市317500 [3]台州市中西医结合医院泌尿外科,浙江省台州市317523

出　　处：《中国超声医学杂志》2024年第8期932-935,共4页Chinese Journal of Ultrasound in Medicine

摘　　要：目的分析经直肠剪切波弹性成像(SWE)联合血清酸性磷酸酶(ACP)、游离前列腺特异抗原/总前列腺特异抗原(FPSA/TPSA)预测前列腺癌根治术(RP)后生化复发(BCR)。方法回顾性选取行RP的102例前列腺癌(PC)患者临床资料。根据术后BCR,将患者分为复发组(22例)及未复发组(80例)。比较两组SWE参数[弹性模量最大值(Emax)、弹性模量平均值(Emean)]、ACP、FPSA/TPSA;建立比例风险回归模型(Cox);采用受试者工作特征(ROC)曲线分析SWE参数、ACP、FPSA/TPSA对PC患者RP术后BCR的预测价值;采用决策曲线分析以上参数预测PC患者RP术后BCR的价值。结果Cox回归分析Emax、Emean、ACP、FPSA/TPSA是影响PC患者RP术后BCR的因素(P<0.05);ROC分析联合检测的曲线下面积(AUC)为0.993;决策曲线分析阈值0.003~1.000范围内,联合预测PC患者RP术后BCR的净收益率优于单独的净收益率。结论经直肠SWE参数Emax、Emean联合血清ACP、FPSA/TPSA在预测PC患者RP术后BCR具有一定临床价值。Objective To analyze the value of shear wave elastography(SWE)parameters combined with serum acid phosphatase(ACP)and free prostate specific antigen/total prostate specific antigen(FPSA/TPSA)in predicting biochemical recurrence(BCR)after radical prostatectomy(RP)for prostate cancer(PC).Methods The clinical data of 102 PC patients who underwent RP were retrospectively selected and were divided into the recurrence group(22 cases)and non-recurrence group(80 cases),according to the postoperative BCR.The SWE parameters maximum elastic modulus(Emax),mean elastic modulus(Emean)J,ACP and FPSA/TPSA between the two groups were collected and compared.The Cox and receiver operating characteristic(ROC)curve were used to analyze the predictive value of SWE parameters,ACP and FPSA/TPSA for postoperative BCR in PC patients underwent RP.The value of using decision curve analysis of the above parameters to predict postoperative BCR in PC patients underwent RP.Results The Cox showed that Emax,Emean,ACP and FPSA/TPSA were the influencing factors of postoperative BCR in PC patients underwent RP(P<0.05).The ROC showed that the area under the curve(AUC)of the combined detection of Emax,Emean,ACP and FPSA/TPSA was 0.993.The decision curve showed that within the threshold range of 0.003 to 1.00O,the combined prediction of Emax,Emean,ACP and FPSA/TPSA for the net return rate of BCR in PC patients after RP was better than the net return rate alone.Conclusions The transrectal SWE parameters Emax and Emean combined with serum ACP and FPSA/TPSA have certain value in predicting the BCR of PC patients after RP.

关 键 词：前列腺癌 剪切波弹性成像 酸性磷酸酶 游离前列腺特异抗原/总前列腺特异抗原 生化复发 

分 类 号：R737.25[医药卫生—肿瘤] R445.1[医药卫生—临床医学]