Autocatalytic bifunctional supramolecular hydrogels for osteoporotic bone repair  

作　　者：Zhihui Han Xiang Gao Yuanjie Wang Cheng Huang Hao Song Shuning Cheng Xiaoyuan Yang Xiaoliang Cui Jie Wu Kailu Wei Liang Cheng 

机构地区：[1]Institute of Functional Nano&Soft Materials(FUNSOM),Collaborative Innovation Center of Suzhou Nano Science and Technology,Soochow University,Suzhou 215123,China [2]Department of Orthopedics,The Second Affiliated Hospital of Soochow University,Suzhou 215004,China [3]Macao Institute of Materials Science and Engineering,Macao University of Science and Technology,Taipa 999078,China

出　　处：《National Science Review》2024年第7期257-272,共16页国家科学评论（英文版）

基　　金：partially supported by the National Key R&D Program of China(2022YFB3804600 and 2021YFF0701800);the National Natural Science Foundation of China(U20A20254 and 52072253);the Collaborative Innovation Center of Suzhou Nano Science and Technology,Suzhou Key Laboratory of Nanotechnology and Biomedicine,the Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20211544);the Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices,Soochow University(KJS2212);the Overseas Expertise Introduction Project for Discipline Innovation(111 Project);the Joint International Research Laboratory of Carbon-Based Functional Materials and Devices,Suzhou Key Laboratory of Nanotechnology and Biomedicine,and the Key Laboratory of Structural Deformities in Children of Suzhou(SZS2022018).

摘　　要：Conventional bone scaffolds,which are mainly ascribed to highly active osteoclasts and an inflammatory microenvironment with high levels of reactive oxygen species and pro-inflammatory factors,barely satisfy osteoporotic defect repair.Herein,multifunctional self-assembled supramolecular fiber hydrogels(Ce–Aln gel)consisting of alendronate(Aln)and cerium(Ce)ions were constructed for osteoporotic bone defect repair.Based on the reversible interaction and polyvalent cerium ions,the Ce–Aln gel,which was mainly composed of ionic coordination and hydrogen bonds,displayed good injectability and autocatalytic amplification of the antioxidant effect.In vitro studies showed that the Ce–Aln gel effectively maintained the biological function of osteoblasts by regulating redox homeostasis and improved the inflammatory microenvironment to enhance the inhibitory effect on osteoclasts.Ribonucleic acid(RNA)sequencing further revealed significant downregulation of various metabolic pathways,including apoptosis signaling,hypoxia metabolism and tumor necrosis factor-alpha(TNF-α)signaling via the nuclear factor kappa-B pathway after treatment with the Ce–Aln gel.In vivo experiments showed that the clinical drug-based Ce–Aln gel effectively promoted the tissue repair of osteoporotic bone defects by improving inflammation and inhibiting osteoclast formation at the defect.Notably,in vivo systemic osteoporosis was significantly ameliorated,highlighting the strong potential of clinical translation for precise therapy of bone defects.

关 键 词：AUTOCATALYSIS supramolecular hydrogel ANTI-INFLAMMATION osteoporosis bone defect 

分 类 号：O641.3[理学—物理化学]