中草药相关肝损伤的表型特征及毒理机制  

Phenotypic characteristics and toxicological mechanisms of herb-induced liver injury

作　　者：何婷婷 柏兆方 王伽伯 肖小河 HE Tingting;BAI Zhaofang;WANG Jiabo;XIAO Xiaohe(Senior Department of Hepatology,Department of Traditional Chinese Medicine,the Fifth Medical Center of PLA General Hospital,Beijing 100039,China;School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China)

机构地区：[1]解放军总医院第五医学中心肝病医学部中医肝病科,北京100039 [2]首都医科大学中医药学院,北京100069

出　　处：《临床肝胆病杂志》2024年第8期1525-1532,共8页Journal of Clinical Hepatology

基　　金：国家自然科学基金(82074112);国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-C-202005);国家自然科学基金联合基金重点项目(U23A20519)。

摘　　要：为科学看待中草药安全性问题,进一步满足人们日益增长的健康需求,与时俱进深化中草药肝损伤研究尤为必要。本文从中草药相关肝损伤的表型特征及毒理机制两方面开展论述,强调不能局限于过去传统中草药固有毒性的认知模式,还应认识到特异质毒性、间接型毒性和混合型毒性等新的类型,这些类型为认识中草药相关肝损伤毒理机制提供了全新视角,对了解中草药相关肝损伤表型和毒理机制十分重要。In order to deal with the problem of the safety of Chinese herbal medicine in a scientific way and further meet the growing health needs of people,it is particularly important to deepen the research on herb-induced liver injury.This article elaborates on the phenotypic characteristics and toxicological mechanisms of herb-induced liver injury and emphasizes that it should not only rely on the previous knowledge of the toxicity of Chinese herbal medicine,but also understand the new types of idiosyncratic toxicity,indirect toxicity,and mixed toxicity,which provide a new perspective for understanding the toxicological mechanisms of herb-induced liver injury and are of great importance to investigate the phenotype and toxicological mechanism of herb-induced liver injury.

关 键 词：中草药 化学性与药物性肝损伤 中药毒理学 

分 类 号：R575[医药卫生—消化系统]