补体调节因子与视神经脊髓炎谱系疾病的研究进展  

Research progress of complement regulatory factor and neuromyelitis optica spectrum disorders

作　　者：韩梦雨 金明[1] HAN Mengyu;JIN Ming(Ophthalmology Department of China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院眼科,北京100029

出　　处：《海南医学院学报》2024年第16期1276-1280,共5页Journal of Hainan Medical University

基　　金：国家自然科学基金项目(82174440);中央高水平医院临床科研业务费;中日友好医院“菁英计划”人才培育工程(ZRJY2021-QM24)。

摘　　要：视神经脊髓炎谱系疾病(NMOSD)是一种获得性、异质性神经眼科交叉性罕见免疫性疾病,特异性高发于视神经和脊髓等中枢神经系统部位,有严重的致残致盲性。虽然补体在NMOSD发病中的重要性已被证实,但膜补体调节因子在NMOSD发病机制中的关键调控作用尚不完全清楚,论述其在NMOSD发病中的生理和病理作用,可能成为解释NMOSD中枢发病的重要原因之一。本文重点回顾近些年来与NMOSD发病相关的补体调节因子CD46、CD55和CD59的研究进展,试图分析、综述补体调节因子在NMOSD发病机制中的作用现状及未来发展前景。Neuromyelitis optic spectrum disease(NMOSD)is a rare acquired and heterogeneous neuro-ophthalmic crossover disease.It specifically occurs in the central nervous system such as the optic nerve and spinal cord,causing severe disability and blindness.Although the importance of complement in the pathogenesis of NMOSD has been confirmed,the key regulatory role of membrane complement regulatory factor in the pathogenesis of NMOSD is not fully understood.Discussing its physiological and pathological role in the pathogenesis of NMOSD may be one of the important reasons to explain the central pathogenesis of NMOSD.This review focuses on the recent research progress of complement regulatory factors CD46,CD55 and CD59 related to the pathogenesis of NMOSD,and attempts to analyze and review the current status and future development prospects of comple⁃ment regulatory factors in the pathogenesis of NMOSD.

关 键 词：视神经脊髓炎谱系疾病 补体调节因子 CD46 CD55 CD59 

分 类 号：R744.52[医药卫生—神经病学与精神病学]