桃仁红花煎联合康复训练对脑缺血再灌注损伤患者神经功能及血清MDA、bFGF、PTX3水平的影响  

Effects of Taoren Honghua decoction combined with rehabilitation training on neurological function and serum MDA,bFGF,PTX3 levels in patients with cerebral ischemia-reperfusion injury

作　　者：杨培 朱玉晓 李男 YANG Pei;ZHU Yuxiao;LI Nan(Department of Rehabilitation Medicine,Dingzhou People's Hospital,Dingzhou,Hebei 073000,China;Department of Acupuncture and Moxibustion and Encephalopathy,Langfang Hospital of Traditional Chinese Medicine,Langfang,Hebei 065000,China)

机构地区：[1]定州市人民医院康复医学科,河北定州073000 [2]廊坊市中医医院针灸脑病科,河北廊坊065000

出　　处：《国际检验医学杂志》2024年第16期2005-2009,共5页International Journal of Laboratory Medicine

基　　金：2023年度中医药类科学研究课题计划(2023298)。

摘　　要：目的探讨桃仁红花煎联合康复训练对脑缺血再灌注损伤(CIRI)患者神经功能及血清丙二醛(MDA)、碱性成纤维细胞生长因子(bFGF)、正五聚蛋白3(PTX3)水平的影响。方法选取2020年6月至2023年5月在定州市人民医院就诊的100例CIRI患者作为研究对象,随机分为治疗组(50例)和对照组(50例)。对照组给予常规治疗结合康复训练,治疗组在对照组基础上给予桃仁红花煎治疗。比较两组患者治疗效果,治疗前后美国国立卫生研究院卒中量表(NIHSS)评分和日常生活能力评定量表(ADL)评分及各指标水平差异,并记录不良反应发生情况。结果治疗组总有效率[86.00%(43/50)]显著高于对照组[68.00%(34/50)],差异有统计学意义(P<0.05)。与治疗前相比,治疗组和对照组治疗后NIHSS评分显著降低,ADL评分显著升高,差异有统计学意义(P<0.05)。治疗后,与对照组相比,治疗组NIHSS评分显著降低,ADL评分显著升高,差异有统计学意义(P<0.05)。治疗后,与对照组相比,治疗组MDA和PTX3水平显著降低,超氧化物歧化酶、bFGF、胰岛素样生长因子1和血管内皮生长因子水平显著升高,差异有统计学意义(P<0.05)。治疗组总不良反应发生率[12.00%(6/50)]显著低于对照组[30.00%(15/50)],差异有统计学意义(P<0.05)。结论桃仁红花煎联合康复训练对CIRI患者有较好的治疗效果,可改善患者神经功能。Objective To investigate the Effects of Taoren Honghua decoction combined with rehabilitation training on neurological function and serum malondialdehyde(MDA),basic fibroblast growth factor(bFGF)and pentraxin 3(PTX3)levels in patients with cerebral ischemia-reperfusion injury(CIRI).Methods A total of 100 CIRI patients treated in Dingzhou People's Hospital from June 2020 to May 2023 as the study objects were randomly divided into treatment group(50 cases)and control group(50 cases).The control group was given routine treatment combined with rehabilitation training,and the treatment group was given Taoren Honghua decoction on the basis of the control group.The treatment effect,the score of National Institutes of Health Stroke Scale(NIHSS)and the score of Daily Living Ability Scale(ADL)before and after treatment were compared between the two groups,and the adverse reactions were recorded.Results The total effective rate of the treatment group[86.00%(43/50)]was significantly higher than that of the control group[68.00%(34/50)],and the difference was statistically significant(P<0.05).Compared with before treatment,the NIHSS score of the treatment group and the control group was significantly decreased after treatment,and the ADL score was significantly increased,with statistical significance(P<0.05).After treatment,compared with the control group,the NIHSS score in the treatment group was significantly decreased,and the ADL score was significantly increased,with statistical significance(P<0.05).After treatment,compared with the control group,the levels of MDA and PTX3 in the treatment group were significantly decreased,while the levels of superoxide dismutase,bFGF,insulin-like growth factor 1 and vascular endothelial growth factor were significantly increased in the treatment group,with statistical significance(P<0.05).The incidence of adverse reactions in the treatment group[12.00%(6/50)]was significantly lower than that in the control group[30.00%(15/50)],and the difference was statistically significant(P<0.05).Conc

关 键 词：脑缺血再灌注损伤 桃仁红花煎 康复训练 丙二醛 

分 类 号：R743.3[医药卫生—神经病学与精神病学]