DNA甲基化在HPV相关宫颈癌中的研究进展  

Research advances on roles of DNA methylation in HPV-associated cervical cancer

作　　者：刘秤华 陈敖峥 丘瑾 王光花 LIU Chenghua;CHEN Aozheng;QIU Jin;WANG Guanghua(Department of Obstetrics and Gynecology,Tongren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200336,China)

机构地区：[1]上海交通大学医学院附属同仁医院妇产科,上海200336

出　　处：《同济大学学报（医学版）》2024年第4期600-606,共7页Journal of Tongji University(Medical Science)

基　　金：上海市长宁区区级项目(RCJD2021S01);上海市长宁区区级项目(CNKW2022Y12)。

摘　　要：宫颈癌是女性最常见的恶性肿瘤之一,与高危型人乳头瘤病毒持续感染密切相关。DNA甲基化作为最主要的表观遗传修饰之一,其对染色质结构和基因转录具有重要调节功能,异常DNA甲基化水平和分布模式与癌症等多种人类疾病密切相关。近年来,国内外关于宫颈癌人乳头瘤病毒DNA甲基化及宿主DNA甲基化的研究越来越多,结果显示两者在宫颈癌演变过程中发挥着重要作用。本文对DNA甲基化在高危型人乳头瘤病毒相关宫颈癌中致癌机制及临床应用现状进行综述。Cervical cancer is one of the most common cancers in women,and persistent high-risk human papillomavirus(HR-HPV)infection has been implicated in the development of cervical cancer.DNA methylation as the most important epigenetic modification,has an important regulatory function on chromatin structure and gene transcription,and aberrant DNA methylation levels and distribution patterns are closely related to a variety of human diseases such as cancer.In recent years,there has been an increasing number of domestic and international studies on human papillomavirus DNA methylation and host DNA methylation in cervical cancer,and it has been found that DNA methylation plays an important role in the evolution of cervical cancer.This article presents a review on the mechanisms of DNA methylation in HPV-associated cervical cancer and its current status in clinical application.

关 键 词：人乳头瘤病毒 DNA甲基化 宫颈癌 致癌机制 

分 类 号：R737.33[医药卫生—肿瘤]