Perspectives on potential neuroprotective role of albumin in acute ischemic stroke  

作　　者：Yuanyuan Liu Xiao Dong Xuehong Chu Ran Meng Chuanhui Li Chen Zhou Chuanjie Wu Xunming Ji 

机构地区：[1]Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [2]Department of Neurology and Stroke Center,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [3]China-America Institute of Neuroscience and Beijing Institute of Geriatrics,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [4]Beijing Institute for Brain Disorders,Capital Medical University,Beijing 100069,China

出　　处：《Journal of Translational Neuroscience》2023年第2期1-6,共6页转化神经科学电子杂志（英文）

摘　　要：Albumin is the most abundant protein in plasma and is synthesized primarily in the liver.It has a variety of biological roles,such as increasing colloid osmotic pressure, and performing antioxidant, anti-inflam-matory,and substance transportation functions.Several studies have confirmed that albumin has neuroprotective effects and it has been used in the treatment of cerebral edema and increased intracranial pressure.In this review we focus on the neuroprotective effects of albumin in ischemic stroke,such as the reduction of cerebral edema, antioxidant effects, protection of neuronal cell membranes, and increased cerebral blood flow. In addition, we summarize preclinical and clinical studies of albumin in ischemic stroke. We believe that the neuroprotective role of albumin should be re-investigated in the era of reperfusion therapy.

关 键 词：ALBUMIN acute ischemic stroke NEURO-PROTECTION reperfusion therapy 

分 类 号：R743[医药卫生—神经病学与精神病学]