Clinical features of AMPAR2 antibody-positive autoimmune encephalitis with gastrointestinal hemorrhage: a case report  

作　　者：Yi Bao Zhixuan Chen Yong Liu Jun Chen 

机构地区：[1]Department of Neurology,Taihe Hospital of Shiyan,Affiliated Hospital of Hubei University of Medicine,Shiyan 442000,China

出　　处：《Journal of Translational Neuroscience》2023年第3期28-32,共5页转化神经科学电子杂志（英文）

基　　金：Undergraduate Innovation and Entrepreneur-ship Program Project of Hubei University of Medicine(X202210929021);Scientific research program of Hubei Provincial Department of education in 2019(Q20192103).

摘　　要：Objective:To describe the clinical features of autoimmune encephalitis complicated with gastrointestinal hemorrhage.Methods:The clinical data of one patient whose initial symptom was mental abnormality were collected and the related examinations,such as cerebrospinal fluid and magnetic resonance imaging (MRI),were improved.Results: Cerebrospinal fluid examination found that anti-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor(AMPAR)2 antibody was strongly positive,although the patient had repeated gastrointestinal hemorrhage but,after hormone combined with immunoglobulin treatment,the symptoms gradual-ly improved.Conclusion:Mental disorders are not all psychosis,and autoimmune encephalitis should not be ignored.It is very important to perform anti-AMPAR encephalitis antibody test;accurate diagnosis and timely treatment can improve the prognosis.

关 键 词：gastrointestinal hemorrhage autoim-mune encephalitis α-Amino-3-hydroxy-5-methylisox-azole-4-propionic acid subtype glutamate receptor(AM-PAR) cerebrospinal fluid 

分 类 号：R573.2[医药卫生—消化系统] R742[医药卫生—内科学]