血清LDH、ApoA1、TSGF水平与结直肠癌患者临床病理特征的相关性分析及联合诊断价值  

Correlation analysis of serum LDH,ApoA 1,TSGF levels and clinicopathological features in patients with colorectal cancer and value of combined diagnosis

作　　者：王小龙 崔艳青 WANG Xiaolong;CUI Yanqing(Clinical Laboratory,Hebi People's Hospital,Hebi,Henan 458000,China)

机构地区：[1]河南省鹤壁市人民医院检验科,458000

出　　处：《淮海医药》2024年第4期337-341,共5页Journal of Huaihai Medicine

摘　　要：目的:探究乳酸脱氢酶(LDH)、载脂蛋白A1(ApoA1)、肿瘤特异性生长因子(TSGF)水平与结直肠癌患者临床病理特征相关性,分析其对结直肠癌的诊断价值。方法:选取2021年1月—2023年1月某院收治的105例结直肠癌患者设为结直肠癌组,同期结直肠腺瘤患者56例设为结直肠腺瘤组,健康体检志愿者35例设为对照组。比较3组血清LDH、ApoA1、TSGF水平。观察结直肠癌组不同临床病理特征者血清LDH、ApoA1、TSGF水平变化,并分析其与临床病理特征相关性;采用受试者工作特征曲线(ROC)分析血清LDH、ApoA1、TSGF水平对结直肠癌的诊断效能。结果:结直肠癌组血清LDH、TSGF水平分别为(302.16±99.52)U/L、(68.52±21.84)U/mL,高于结直肠腺瘤组[(267.49±82.61)U/L、(57.49±16.16)U/mL]和对照组[(201.98±66.36)U/L、(43.28±14.18)U/mL],血清ApoA1水平[(1.33±0.41)g/mL]低于结直肠腺瘤组[(1.58±0.51)g/mL]和对照组[(1.80±0.58)g/mL],差异均有统计学意义(P<0.05)。随着TNM分期增加、淋巴结转移、浆膜浸润发生,血清LDH、TSGF水平呈上升趋势,ApoA1水平呈下降趋势,而随着分化程度增高,血清LDH、TSGF水平呈下降趋势,ApoA1水平呈上升趋势,差异有统计学意义(P<0.05)。血清LDH、TSGF与TNM分期、淋巴结转移、浆膜浸润呈正相关(r LDH=0.526、0.632、0.485;r TSGF=0.574、0.419、0.503,P均<0.05),与分化程度呈负相关(r LDH=-0.412;r TSGF=-0.567,P均<0.05),而ApoA1与TNM分期、淋巴结转移、浆膜浸润呈负相关(r=-0.528、-0.557、-0.601,P<0.05),与分化程度呈正相关(r=0.496,P<0.05)。血清LDH、ApoA1、TSGF联合检测诊断结直肠癌的AUC为0.901,大于单项指标诊断。结论:结直肠癌患者血清LDH、TSGF呈高表达,ApoA1呈低表达,其中血清LDH、TSGF与TNM分期、淋巴结转移、浆膜浸润呈正相关,与分化程度呈负相关,而ApoA1与之相反,联合检测其水平对结直肠癌具有一定诊断价值。Objective:To investigate the correlation of levels of lactate dehydrogenase(LDH),apolipoprotein A1(ApoA1)and tumor specific growth factor(TSGF)with clinicopathological features of colorectal cancer patients,and to analyze its diagnostic value in colorectal cancer.Methods:A total of 105 patients with colorectal cancer admitted to a hospital from January 2021 to January 2023 were selected as a colorectal cancer group,56 patients with colorectal adenoma during the same period were chosen as a colorectal adenoma group,and 35 healthy volunteers were recruited as a control group.Serum levels of LDH,ApoA1 and TSGF were compared among the groups.Changes of serum LDH,ApoA1 and TSGF in colorectal cancer patients with different clinicopathological features were observed,and their correlation with the clinicopathological features was analyzed.Receiver operating characteristic curve(ROC)was used to analyze the diagnostic efficacy of serum LDH,ApoA1 and TSGF in colorectal cancer.Results:The levels of serum LDH and TSGF in the colorectal cancer group were(302.16±99.52)U/L and(68.52±21.84)U/mL,respectively,which were higher than those in the colorectal adenoma group[(267.49±82.61)U/L and(57.49±16.16)U/mL]and the control group[(201.98±66.36)U/L and(43.28±14.18)U/mL].The level of serum ApoA1[(1.33±0.41)g/mL]was lower than that in the colorectal adenoma group[(1.58±0.51)g/mL]and the control group[(1.80±0.58)g/mL],the differences being statistically significant(P<0.05).With the increase of TNM staging,lymph node metastasis,and serosal invasion,the levels of serum LDH and TSGF showed an upward trend,while the level of ApoA1 a downward trend.With the increase of differentiation degree,the levels of serum LDH and TSGF presented a downward trend,while the level of ApoA1 an upward trend,with significant differences(P<0.05).Serum LDH,TSGF were positively correlated with TNM staging,lymph node metastasis,and serosal invasion(r LDH=0.526,0.632,0.485,P<0.05;r TSGF=0.574,0.419,0.503,P<0.05),and negatively correlated with differentiat

关 键 词：结直肠肿瘤 乳酸脱氢酶 载脂蛋白A1 肿瘤特异性生长因子 病理特征 

分 类 号：R735.34[医药卫生—肿瘤]