甲状腺癌组织HSP70表达与临床病理特征及术后复发的关联性分析  

Exploration of relationship between HSP 70 expression in thyroid cancer tissue and clinical pathological characteristics and postoperative recurrence

作　　者：张修志 翟慧萍 魏哲 ZHANG Xiuzhi;ZHAI Huiping;WEI Zhe(Department of Functional Examination,The Second People's Hospital of Xinxiang City,Henan 453000,China)

机构地区：[1]河南省新乡市第二人民医院功检科,453000

出　　处：《淮海医药》2024年第4期346-350,共5页Journal of Huaihai Medicine

摘　　要：目的:探讨甲状腺癌组织热休克蛋白70(HSP70)表达与临床病理特征及术后复发的关系。方法:回顾性分析2018年6月—2019年12月某院行手术治疗的165例甲状腺癌患者的临床资料,术中提取研究对象的癌组织和癌旁正常组织标本,采用免疫组化法检测甲状腺癌组织和癌旁正常组织HSP70表达水平,分析不同临床病理特征的甲状腺癌患者癌组织HSP70表达,采用单因素和多因素Logistic回归分析影响甲状腺癌术后复发的影响因素。结果:甲状腺癌组织中HSP70表达水平(0.87±0.23)高于癌旁正常组织(0.41±0.07),差异有统计学意义(P<0.001)。肿瘤最大直径≤4 cm、病理类型为分化型、TNM分期为Ⅰ~Ⅱ期的甲状腺癌患者癌组织中HSP70表达水平分别为(0.83±0.23)、(0.72±0.19)、(0.69±0.15),低于肿瘤最大直径>4 cm、病理类型为非分化型、TNM分期Ⅲ~Ⅳ期患者癌组织的(0.95±0.27)、(1.39±0.32)、(1.02±0.28),有淋巴结转移的甲状腺癌患者癌组织中HSP70表达水平为(0.99±0.26),高于无淋巴结转移患者癌组织的(0.75±0.21),差异有统计学意义(P<0.05)。甲状腺癌患者术后3年复发率为23.64%。多因素Logistic回归分析结果显示,肿瘤最大直径>4 cm、病理类型为非分化型、TNM分期为Ⅲ~Ⅳ期、有淋巴结转移、甲状腺癌组织HSP70表达升高是甲状腺癌术后复发的独立危险因素。结论:甲状腺癌组织中HSP70呈高表达,甲状腺癌组织中HSP70高表达、肿瘤最大直径>4 cm、病理类型为非分化型、TNM分期Ⅲ~Ⅳ期、有淋巴结转移均是甲状腺癌术后复发的独立危险因素。Objective:To investigate the relationship between the expression of heat shock protein 70(HSP70)in thyroid cancer tissue and clinical pathological characteristics and postoperative recurrence.Methods:A retrospective analysis was conducted on the clinical data of 165 patients with thyroid cancer who underwent surgical treatment in a hospital from June 2018 to December 2019.The expressions of HSP70 in thyroid cancer tissue and adjacent normal tissues were detected using immunohistochemical methods.The expressions of HSP70 in thyroid cancer tissues with different clinical pathological characteristics were compared.The influencing factors of postoperative recurrence in thyroid cancer were analyzed using univariate and multivariate Logistic regression analysis.Results:The expression of HSP70 in thyroid cancer tissue(0.87±0.23)was higher than that in adjacent normal tissue(0.41±0.07),and the difference was statistically significant(P<0.001).The expressions of HSP70 in thyroid cancer tissues of patients with maximum tumor diameter>4cm,non-differentiated,TNM stages III~IV,and lymph node metastasis(0.95±0.27,1.39±0.32,1.02±0.28,0.99±0.26)were higher than those of patients with maximum tumor diameter≤4cm,differentiated,TNM stages I~II,and no lymph node metastasis(0.83±0.23,0.72±0.19,0.69±0.15,0.75±0.21),the differences being statistically significant(P<0.05).The 3-year recurrence rate of thyroid cancer patients after surgery was 23.64%(39/165).The results of multivariate Logistic regression analysis showed that maximum tumor diameter>4cm(95%CI:1.311~5.130,P=0.006),non-differentiated(95%CI:1.895~7.500,P<0.001),TNM stage III-IV(95%CI:1.567~6.105,P=0.001),lymph node metastasis(95%CI:1.205~4.226,P=0.013),and elevated HSP70 expression(95%CI:1.568~7.976,P=0.002)in thyroid cancer tissue were independent risk factors for postoperative recurrence of thyroid cancer(P<0.05).Conclusion:HSP70 is highly expressed in thyroid cancer tissue,which is related to tumor size,pathological type,TNM staging,lymph node metastasis and p

关 键 词：甲状腺肿瘤 热休克蛋白70 病理特征 术后复发 

分 类 号：R736.1[医药卫生—肿瘤]