防己黄芪汤联合EC方案治疗乳腺癌疗效观察及对血清乳酸脱氢酶、ki-67水平的影响  

Observation on Curative Effect of Fangij iHuangqi Decoction Combined with EC Regimen on Breast Cancer and Its Effect on Serum Lactate Dehydrogenase and ki-67 Levels

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作  者:陈运子 余海涛 陈倚天 CHEN Yunzi;YU Haitao;CHEN Yitian(Zhejiang Chinese Medical University,Hangzhou Zhejiang 310053,China;Lanxi People's Hospital,Lanxi Zhejiang 321100,China)

机构地区:[1]浙江中医药大学,浙江杭州310053 [2]兰溪市人民医院,浙江兰溪321100

出  处:《新中医》2024年第14期158-162,共5页New Chinese Medicine

摘  要:目的:观察防己黄芪汤联合表柔比星^(+)环磷酰胺(EC)方案治疗乳腺癌的临床疗效及对血清乳酸脱氢酶(LDH)、ki-67水平的影响。方法:将100例乳腺癌患者按随机数字表法分为化疗组和中药组各50例。化疗组采取EC方案治疗,中药组在化疗组基础上加用防己黄芪汤治疗。连续治疗4个疗程,比较2组近期疗效、生活质量量表评分、LDH、ki-67、免疫细胞(CD4^(+)、CD8^(+)以及CD4^(+)/CD8^(+))水平及并发症发生情况。结果:治疗后,中药组总有效率为60.00%,化疗组为40.00%,2组比较,差异有统计学意义(P<0.05);2组生活质量量表评分均较治疗前升高(P<0.05),且中药组生活质量量表评分高于化疗组(P<0.05)。治疗后,2组CD8^(+)、LDH、ki-67水平均较治疗前降低(P<0.05),CD4^(+)、CD4^(+)/CD8^(+)水平均较治疗前升高(P<0.05);且中药组CD8^(+)、LDH、ki-67水平低于化疗组(P<0.05),CD4^(+)、CD4^(+)/CD8^(+)水平高于化疗组(P<0.05)。治疗后,中药组水肿、脱发、手足综合征以及恶心呕吐等发生率分别为26.00%、22.00%、14.00%、10.00%,化疗组分别为46.00%、44.00%、36.00%、32.00%,2组比较,差异均有统计学意义(P<0.05)。结论:防己黄芪汤联合EC方案治疗乳腺癌临床疗效显著,可下调血清ki-67、LDH水平,改善患者免疫功能及生活质量,且不良反应相对较少。Objective:To observe the clinical effect of Fangji Huangqi Decoction combined with epirubicin+cyclophosphamide(EC)regimen on breast cancer and its effect on serum lactate dehydrogenase(LDH)and ki-67 levels.Methods:A total of 100 cases of patients with breast cancer were divided into the chemotherapy group and the Chinese medicine group according to the random number table method,with 50 cases in each group.The chemotherapy group was treated with EC regimen,and the Chinese medicine group was additionally treated with Fangji Huangqi Decoction based on the treatment of the chemotherapy group.After four consecutive courses of treatment,the short-term efficacy,Quality of Life Scale scores,levels of LDH,ki-67,immune cells(CD4^(+),CD8^(+)and CD4^(+)/CD8^(+))and the incidence of complications were compared between the two groups.Results:After treatment,the total effective rate was 60.00%in the Chinese medicine group and 40.00%in the chemotherapy group,the difference being significant(P<0.05).Quality of Life Scale scores in the two groups were increased when compared with those before treatment(P<0.05),and Quality of Life Scale score in the Chinese medicine group was higher than that in the chemotherapy group(P<0.05).After treatment,the levels of CD8^(+),LDH and ki-67 in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of CD4^(+)and CD4^(+)/CD8^(+)were increased when compared with those before treatment(P<0.05);the levels of CD8^(+),LDH and ki-67 in the Chinese medicine group were lower than those in the chemotherapy group(P<0.05),and the levels of CD4^(+)and CD4^(+)/CD8^(+)were higher than those in the chemotherapy group(P<0.05).After treatment,the incidence of edema,alopecia,hand and foot syndrome,and nausea and vomiting were 26.00%,22.00%,14.00%and 10.00%respectively in the Chinese medicine group,and 46.00%,44.00%,36.00%and 32.00%respectively in the chemotherapy group,differences being significant(P<0.05).Conclusion:Fangji Huangqi Decoction combined with EC regimen has a si

关 键 词:乳腺癌 防己黄芪汤 EC方案 生活质量 KI-67 乳酸脱氢酶 

分 类 号:R737.9[医药卫生—肿瘤]

 

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