血清ESM-1、MMP-7水平联合检测在结直肠癌诊断中的效能  

Efficiency of combined detection of serum ESM-1 and MMP-7 levels in diagnosis of colorectal cancer

作　　者：李正兴 LI Zhengxing(Department of Medical Imaging of Xin County People’s Hospital,Xinyang 465500 Henan,China)

机构地区：[1]新县人民医院医学影像科,河南信阳465500

出　　处：《中国民康医学》2024年第16期125-127,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清内皮细胞特异性分子-1(ESM-1)、基质金属蛋白酶-7(MMP-7)水平联合检测在结直肠癌诊断中的效能。方法:选取2021年7月至2023年6月该院收治的47例结直肠癌患者为研究组,另选取同期该院47名健康体检者为对照组。比较两组、不同临床分期结直肠癌患者血清MMP-7、ESM-1水平,采用Spearman相关性分析血清ESM-1、MMP-7水平与结直肠癌患者临床分期的相关性,并绘制受试者工作特征(ROC)曲线,分析血清ESM-1、MMP-7水平单项及联合检测在结直肠癌诊断中的效能。结果:研究组血清MMP-7、ESM-1水平均高于对照组,差异有统计学意义(P<0.05);Ⅲ~Ⅳ期结直肠癌患者血清MMP-7、ESM-1水平均高于Ⅰ~Ⅱ期患者,差异有统计学意义(P<0.05);Spearman相关性分析结果显示,血清MMP-7、ESM-1水平与结直肠癌患者临床分期均呈正相关(r>0,P<0.05);ROC曲线分析结果显示,血清ESM-1、MMP-7水平单项及联合检测诊断结直肠癌的曲线下面积分别为0.789、0.816、0.902,且联合检测高于二者单项检测。结论:血清ESM-1、MMP-7水平联合检测诊断结直肠癌的效能高于二者单项检测。Objective:To analyze efficiency of combined detection of serum endothelial cell specific molecule-1(ESM-1)and matrix metalloproteinase-7(MMP-7)levels in diagnosis of colorectal cancer.Methods:A total of 47 patients with colorectal cancer admitted to the hospital from July 2021 to June 2023 were selected as the study group,and 47 healthy subjects in the hospital during the same period were selected as the control group.The serum levels of MMP-7 and ESM-1 were compared between the two groups and the patients with different clinical stages of colorectal cancer.Spearman correlation analysis was used to analyze the correlations among the serum ESM-1 and MMP-7 levels and clinical stage of the colorectal cancer patients.The receiver operating characteristic(ROC)curve was drawn to analyze the efficiencies of single and combined detection of serum ESM-1 and MMP-7 levels in the diagnosis of colorectal cancer.Results:The levels of serum MMP-7 and ESM-1 in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of serum MMP-7 and ESM-1 in the patients with stage III-IV colorectal cancer were higher than those in the patients with stage I-II,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that the serum MMP-7 and ESM-1 levels were positively correlated with the clinical stage of the colorectal cancer patients(r>0,P<0.05).The ROC curve showed that the area under the curve of single and combined detection of the serum MMP-7 and ESM-1 levels in the diagnosis of colorectal cancer were 0.789,0.816,0.902,respectively,and the efficiency of combined detection in the diagnosis of colorectal cancer was higher than that of single detection.Conclusions:The efficiency of combined detection of the serum ESM-1 and MMP-7 levels in the diagnosis of colorectal cancer is higher than that of single detection.

关 键 词：内皮细胞特异性分子-1 基质金属蛋白酶-7 结直肠癌 检测 诊断 效能 

分 类 号：R735[医药卫生—肿瘤]