ICP-MS法测定香苏正胃丸中朱砂的含量  

Determination of cinnabar in Xiangsu Zhengwei pills by ICP-MS

作　　者：高立金 李杰 张琳 卢彩会 仇晓晴 GAO Li-jin;LI Jie;ZHANG Lin;LU Cai-hui;QIU Xiao-qing(Langfang Institute for Drug Control,Langfang Hebei 065000)

机构地区：[1]廊坊市药品检验所,河北廊坊065000

出　　处：《中南药学》2024年第7期1883-1885,共3页Central South Pharmacy

基　　金：河北省药品监督管理局科技计划项目(No.2023ZC1002)。

摘　　要：目的建立香苏正胃丸中毒性成分朱砂的含量测定方法。方法香苏正胃丸样品用盐酸-硝酸(3∶1)5 mL超声,使朱砂反应生成可溶性汞盐,用水和2%硝酸稀释,加入金储备液,使含汞和金比例为1∶200,用ICP-MS法对朱砂中的汞进行含量测定。结果汞的质量浓度在0~15 ng·mL^(-1)内与信号强度呈良好的线性关系,回归方程Y=2614X+317,相关系数(r)0.9999,平均回收率为97.6%,RSD为1.7%,3批次样品每丸含朱砂(以硫化汞计)在5.76~5.85 mg内。结论建立的方法简便可靠、准确性高、专属性强,可用于香苏正胃丸质量控制。Objective To determine the toxic component cinnabar in Xiangsu Zhengwei pills.Methods The sample of Xiangsu Zhengwei pills was dissolved in 5 mL hydrochloric acid-nitric acid(3∶1)before ultrasound.The mixture was diluted with water and 2%nitric acid,and a gold reserve solution was added to achieve a mercury to gold ratio of 1∶200,and then diluted with 2%nitric acid to quantitatively analyze the content of mercury in cinnabar by ICP-MS.Results The mercury concentration was in a good linearity with signal intensity within 0~15 ng·mL^(-1).The regression equation was Y=2614X+317,r=0.9999,and the average recovery was 97.6%,with RSD of 1.7%.The content of mercury in cinnabar in 3 batches of samples(calculated as mercury sulfide)ranged 5.76~5.85 mg per pill.Conclusion The method is reliable,accurate,and specific,and can effectively control the content of toxic ingredients in the preparation.

关 键 词：ICP-MS法 香苏正胃丸 毒性成分 朱砂 

分 类 号：R927[医药卫生—药学] R284.1