谷胱甘肽转移酶M1基因多态性与亚洲人群宫颈癌易感性的meta分析  

Meta-analysis of the correlation between the glutathione S-transferase M1 gene polymorphism of Asian women and their cervical cancer susceptibility

作　　者：周青 刘帅妹 林宁 张瑞金 李孟兰 封婕 黄丽丽 吴玉璘 石慧 ZHOU Qing;LIU Shuaimei;LIN Ning;ZHANG Ruijin;LI Menglan;Feng Jie;HUANG Lili;WU Yulin;SHI Hui(Jiangsu Health Development Research Center,National Health and Family Planning CommissionC ontraceptives Adverse Reaction Surveillance Center,Jiangsu Provincial Medical Key Laboratory of Fertility Protectionand Health Technology Assessment,Nanjing,Jiangsu Province,210036)

机构地区：[1]江苏省卫生健康发展研究中心,国家卫健委计划生育药具不良反应监测中心,江苏省生育力保护与卫生技术评估重点实验室,南京210036

出　　处：《中国计划生育学杂志》2024年第8期1720-1726,共7页Chinese Journal of Family Planning

基　　金：江苏省卫生健康发展研究中心自主科研项目(JSHD2021066);江苏省科教能力提升工程(ZDXYS202210);江苏省卫生健康委科研项目(ZD2021030)。

摘　　要：目的:探讨谷胱甘肽转移酶M1(GSTM1)基因多态性与亚洲人群宫颈癌易感性的关系。方法:检索中国知网、万方、PubMed等中英文数据库,收集关于GSTM1基因多态性与亚洲人群宫颈癌易感性相关研究,检索时间为建库至2024年5月,对纳入的研究,运用Stata11.0软件计算OR值和95%CI,评价其相关性。结果:共纳入19项研究,宫颈癌病例组2324例和对照组2611例,meta分析结果显示亚洲人群中GSTM1纯合缺失型与宫颈癌易感性存在明显正相关(OR=1.74,95%CI 1.41~2.14),亚组分析发现,东亚人群(OR=1.54,95%CI 1.21~1.97)、中亚人群(OR=8.32,95%CI 2.84~24.36)、南亚人群(OR=2.11,95%CI 1.48~3.02)、中国人群(OR=2.03,95%CI 1.46~2.82)、印度人群(OR=1.89,95%CI 1.39~2.57)、哈萨克斯坦人群(OR=8.32,95%CI 2.84~24.36)和巴基斯坦人群(OR=5.52,95%CI 2.34~13.07)的GSTM1纯合缺失型均与宫颈癌易感性存在显著关联。结论:GSTM1纯合缺失型可能会增加亚洲人群宫颈癌发生风险。Objective:To explore the correlation between the glutathione S-transferase M1(GSTM1)gene polymorphism of women in A sia and their cervical cancer susceptibility.Methods:The articles about the correlation between GSTM1 gene polymorphism of women in Asia and their cervical cancer susceptibility were searched in Chinese and English databases,such as CNKI,Wanfang,Pubmed,and so on.The retrieval time of the database was from the establishment of the database to May 2024.The odds ratio(OR)and its 95%confidence interval(CI)of the correlation were calculated by Stata11.0 software.Results:A total of 19 case-control studies were included,including 2324 women with cervical cancer in the case group and 2611 women without cervical cancer in the control group.Meta-analysis results showed that the homozygous deletion of GSTM1 genotype of the Asian women was significantly associated with their cervical cancer susceptibility(OR=1.74,95%CI 1.41-2.14).The subgroup analysis showed that the homozygous deletion of GSTM1 genotype of the women in east Asian(OR=1.54,95%CI 1.21-1.97),of the women in central Asian(OR=8.32,95%CI 2.84-24.36),of the women in south Asian(OR=2.11,95%CI 1.48-3.02),of the women in China(OR=2.03,95%CI 1.46-2.82),of the women in Indian(OR=1.89,95%CI 1.39-2.57),of the women in Kazakhstan(OR=8.32,95%CI 2.84-24.36),or of the women in Pakistan populations(OR=5.52,95%CI 2.34-13.07)was significantly associated with their cervical cancer susceptibility.Conclusion:The homozygous deletion of GSTM1 genotype of the Asian women may increase the risk of their cervical cancer occurrence.

关 键 词：宫颈癌 亚洲女性 谷胱甘肽转移酶M1 基因多态性 META分析 

分 类 号：R737.33[医药卫生—肿瘤]