HPV-DNA联合SCC-Ag、CA19-9、AFP检测诊断宫颈癌的临床价值  

Clinical value of human papillomavirus DNA detection combined with the levels of squamous cell carcinoma antigen,carbohydrate antigen 19-9 and alpha-fetoprotein for diagnosing cervical cancer

作　　者：郝培培 张赛英 孙斌 孙文超 HAO Peipei;ZHANG Saiying;SUN Bin;SUN Wenchao(Hangzhou Obstetrics and Gynecology Hospital Hangzhou,Zhejiang Province,310000)

机构地区：[1]浙江省杭州市妇产科医院,310000

出　　处：《中国计划生育学杂志》2024年第8期1923-1926,1932,共5页Chinese Journal of Family Planning

摘　　要：目的:分析人乳头瘤病毒DNA(HPV-DNA)联合鳞状细胞癌抗原(SCC-Ag)、糖类抗原19-9(CA19-9)及甲胎蛋白(AFP)检测在宫颈癌诊断中的临床价值。方法:回顾性收集2018年3月-2022年3月本院诊治的宫颈癌患者、宫颈良性病变患者各80例临床资料,分别纳入宫颈癌组、良性病变组,同期健康体检女性50例纳入对照组,比较3组以及宫颈癌组不同FIGO分期患者血清SCC-Ag、CA19-9、AFP表达水平及HPV-DNA、SCC-Ag、CA19-9、AFP阳性率,以病理诊断为“金标准”,评价HPV-DNA、SCC-Ag、CA19-9、AFP单独及联合检测对宫颈癌的诊断效能。结果:宫颈癌组血清SCC-Ag、CA19-9、AFP表达水平均高于良性病变组与对照组,HPV-DNA、SCC-Ag、CA19-9、AFP阳性率均高于良性病变组与对照组,且宫颈癌组Ⅲ~Ⅳ期患者血清SCC-Ag、CA19-9、AFP表达水平均高于Ⅰ~Ⅱ期患者,HPV-DNA、CA19-9、AFP阳性率均高于Ⅰ~Ⅱ期患者(均P<0.05);HPV-DNA、SCC-Ag、CA19-9、AFP联合检测诊断宫颈癌的敏感度(96.3%)、准确度(91.8%)均高于各项单独检测,AFP诊断特异度最高达100.0%(P<0.05)。结论:HPV-DNA联合SCC-Ag、CA19-9、AFP检测可提高宫颈癌的诊断效能。Objective:To analyze the clinical value of human papillomavirus DNA(HPV-DNA)detection combined with the levels of squamous cell carcinoma antigen(SCC-Ag),carbohydrate antigen 19-9(CA19-9)and alpha-fetoprotein(AFP)for diagnosing cervical cancer.Methods:The clinical data of 80 women with cervical cancer(in group A)and 80patients with benign cervical lesions(in group B)between March 2018 and March 2022 were collected respectively.50healthy women were enrolled in group C.The expression levels of the serum SCC-Ag,CA19-9 and AFP,and the positive rates of HPV-DNA,SCC-Ag,CA19-9 and AFP of the women were compared among the three groups.In group A,the expression levels of the serum SCC-Ag,CA19-9 and AFP,and the positive rates of HPV-DNA,SCC-Ag,CA19-9 and AFP were compared among the women with different FTGO stages.The results of the pathological diagnosis was used as the"gold standard",the efficiencies of the HPV-DNA level,the SCC-Ag level,the CA19-9 level or the AFP level alone,and the combination of the HPV-DNA and the SCC-Ag CA19-9 and AFP levels of the women for diagnosing their cervical cancer were evaluated.Results:The expression levels of the serum SCC-Ag,CA19-9 and AFP of the women in group A were significantly higher than those of the women in group B and those of the women in group C.The positive rates of HPV-DNA,SCC-Ag,CA19-9 and AFP of the women in group A were also significantly higher than those of the women in group B and those of the women group C.In group A,the expression levels of the serum SCC-Ag,CA19-9 and AFP of the women with stageⅢ-Ⅳcervical cancer were significantly higher than those of the women with stageⅠ-Ⅱcervical cancer,and the positive rates of HPV-DNA,CA19-9 and AFP of the women with stageⅢ-Ⅳcervical cancer were also significantly higher than those of the women with stageⅠ-Ⅱcervical cancer(all P<0.05).The sensitivity(96.3%)and the accuracy(91.8%)of the combination of the HPV-DNA and the SCC-Ag,CA19-9 and AFP levels of the women for diagnosiong their cervical cancer were signif

关 键 词：宫颈癌 人乳头瘤病毒 鳞状细胞癌抗原 糖类抗原19-9 甲胎蛋白 诊断 

分 类 号：R737.33[医药卫生—肿瘤]