间充质干细胞在肿瘤免疫中的调节作用  

Regulatory role of mesenchymal stem cells in tumor immunity

作　　者：秦姗[1] 刘冰 周嘉敏 孙飞虎 郝康 郭卿 张坤娟 刘小军[1] Qin Shan;Liu Bing;Zhou Jiamin;Sun Feihu;Hao Kang;Guo Qing;Zhang Kunjuan;Liu Xiaojun(Department of Hematology,The Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei Province,China;Hebei Yihe Medical Laboratory Center,Shijiazhuang 050000,Hebei Province,China)

机构地区：[1]河北医科大学第二医院血液内科,石家庄050000 [2]河北意和医学检验中心,石家庄050000

出　　处：《国际输血及血液学杂志》2024年第2期133-140,共8页International Journal of Blood Transfusion and Hematology

基　　金：石家庄市科技局科学技术研究与发展计划项目(211460543)。

摘　　要：间充质干细胞(MSC)是一组异质性很强的细胞,可自我更新,向多系分化。MSC来源于多种组织,如骨髓、脂肪组织、脐带Wharton胶等。MSC具有多向分化潜能及免疫调节功能。MSC的免疫调节功能主要是针对炎性反应,而肿瘤作为一种特殊的炎症反应,可引发机体各种免疫细胞参与,因此MSC对肿瘤免疫具有重要调节作用。目前多项研究认为,MSC对肿瘤免疫具有负性调控作用,但是迄今仍有很多MSC对肿瘤免疫影响的现象无法采用该机制解释,MSC在肿瘤免疫中的调节作用尚需更多临床试验数据进一步阐明。笔者拟就MSC通过与淋巴细胞、其他免疫细胞相互作用调节肿瘤免疫的最新研究现状进行阐述。Mesenchymal stem cells(MSC)are a heterogeneous group of cells that are capable of self-renewal and multipotent differentiation.MSC can be derived from various tissues such as bone marrow,adipose tissue,and Wharton′s jelly in umbilical cord.MSC possess both multi-potent differentiation and immune regulatory functions.The immune regulatory function of MSC mainly targets inflammatory reactions,and tumors,as a special form of inflammation,can trigger various immune cells in the body,thus MSC also play an important role in tumor immunity.Currently,most studies believe that MSC have a negative regulatory effect on tumor immunity,but there are still many phenomena of MSC′s impact on tumor immunity that cannot be explained by this mechanism,the regulatory roles of MSC in tumor immunity still require further clarification with more clinical trial data.The author intends to elaborate on the latest research on how MSC regulate tumor immunity through their interaction with lymphocytes and other immune cells.

关 键 词：免疫 细胞 间质干细胞 肿瘤逃逸 肿瘤免疫 肿瘤微环境 免疫调节 

分 类 号：R730.3[医药卫生—肿瘤]