血清Klotho、ACA及VEGF水平与PCI患者认知功能的相关性  

Correlation between serum Klotho,ACA and VEGF levels and cognitive function in patients with progressive cerebral infarction

作　　者：崔亮亮 吴旭鹏 崔丽霞[1] CUI Liang-liang;WU Xu-peng;CUI Li-xia(Department of Neurology,Peace Hospital Affiliated to Changzhi Medical College,Changzhi Shanxi 046000,China)

机构地区：[1]长治医学院附属和平医院神经内科,山西长治046000

出　　处：《临床和实验医学杂志》2024年第14期1471-1474,共4页Journal of Clinical and Experimental Medicine

基　　金：山西省卫健委科研基金项目(编号:20220912)。

摘　　要：目的探讨血清Klotho、抗心磷脂抗体(ACA)及血管内皮生长因子(VEGF)水平与进展性脑梗死(PCI)患者认知功能的相关性。方法回顾性分析2021年8月至2023年8月长治医学院附属和平医院收治的80例PCI患者的临床资料,根据蒙特利尔认知评估量表(MoCA)得分将患者分为认知功能障碍(CD)组(MoCA评分<26分,共31例)与非CD组(MoCA评分≥26分,共49例)。收集患者一般资料[性别、年龄、体重指数、吸烟、饮酒、高血压、糖尿病、高血脂、入院时间、MoCA分值、C反应蛋白(CRP)、血肌酐、血小板计数、天冬氨酸转氨酶(AST)、空腹血糖],比较两组Klotho、ACA、VEGF水平;采取多因素非条件Logistic回归分析对PCI患者发生CD的危险因素进行分析;采取Pearson相关系数分析对Klotho、ACA、VEGF水平与PCI患者认知功能评分的相关性进行分析;通过受试者操作特征(ROC)曲线分析Klotho、ACA、VEGF评估PCI患者发生CD的价值。结果两组的性别、体重指数、吸烟、饮酒、糖尿病、高血脂、入院时间、CRP、血肌酐、血小板计数、AST、空腹血糖组间比较,差异均无统计学意义(P>0.05)。CD组的年龄、高血压人数占比、ACA分别为(65.13±7.08)岁、64.52%、(1.46±0.41)mg/L,均明显高于非CD组[(58.67±8.42)岁、40.82%、(0.86±0.19)mg/L],CD组MoCA评分、Klotho水平、VEGF水平分别为(21.14±2.06)分、(284.19±73.37)pg/mL、(193.21±7.05)pg/mL,均明显低于非CD组[(28.05±1.79)分、(428.46±92.58)pg/mL、(208.43±7.72)pg/mL],差异均有统计学意义(P<0.05)。多因素非条件Logistic回归分析结果显示,年龄、高血压、Klotho水平、ACA水平、VEGF水平是PCI患者发生CD的危险因素(P<0.05)。Pearson相关性分析结果显示,Klotho水平、VEGF水平与PCI患者认知功能评分呈正相关,ACA水平与PCI患者认知功能评分呈负相关,且均有P<0.05。ROC曲线分析结果显示,Klotho水平、ACA水平、VEGF水平评估PCI患者发生CD的曲线下面积分别Objective To investigate the correlation between serum levels of Klotho,anti cardiolipin antibody(ACA)and vascular endothelial growth factor(VEGF)and cognitive function in patients with progressive cerebral infarction(PCI).Methods The clinical data of 80 PCI patients admitted to Peace Hospital Affiliated to Changzhi Medical College from August 2021 to August 2023 were retrospectively analyzed.According to Montreal Cognitive Assessment Scale(MoCA)scores,they were divided into the cognitive dysfunction(CD)group(31 cases with MoCA score<26 points)and the non-CD group(49 cases with MoCA score≥26 points).The general data of patients were collected,and the levels of Klotho,ACA and VEGF were detected.The general data[gender,age,body mass index,smoking,drinking,hypertension,diabetes,hyperlipidemia,admission time,MoCA score,C-reactive protein(CRP),serum creatinine,platelet count,aspartate transaminase(AST),fasting blood glucose]and the levels of Klotho,ACA and VEGF were compared between the two groups.The correlation between Klotho,ACA,VEGF levels and cognitive function scores in patients with PCI was analyzed using Pearson correlation coefficient.The risk factors of CD in patients with PCI were analyzed by Multivariate non-conditional Logistic regression analysis.The value of Klotho,ACA and VEGF in the assessment of CD in patients with PCI was analyze using receiver operating characteristic(ROC)curve.Results There were no statistically significant differences in gender,body mass index,smoking,drinking,diabetes,hyperlipidemia,time of admission,CRP,serum creatinine,platelet count,AST and fasting blood glucose between the two groups(P>0.05).The age,proportion of hypertension and ACA in CD group were(65.13±7.08)years,64.52%and(1.46±0.41)mg/L,respectively,which were significantly higher than those in non-CD group[(58.67±8.42)years,40.82%and(0.86±0.19)mg/L],while the MoCA score,the levels of Klotho and VEGF in group CD were(21.14±2.06)points,(284.19±73.37)pg/mL and(193.21±7.05)pg/mL,respectively,which were significant

关 键 词：脑梗死 血管内皮生长因子类 认知功能 KLOTHO 抗心磷脂抗体 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R446.1[医药卫生—临床医学]