An integrated strategy of UPLC-Q-TOF/MS and HPTLC/PAD-DESI-MSI for the analysis of chemical variations:A case study of Tibetan medicine Tiebangchui  

作　　者：Yue Liu Mengjia Li Xing Fu Yi Zhang Ce Tang 

机构地区：[1]State Key Laboratory of Southwestern Chinese Medicine Resources,School of Ethnic Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China [2]Meishan Hospital of Chengdu University of Traditional Chinese Medicine,Meishan,Sichuan,620010,China [3]Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China

出　　处：《Journal of Pharmaceutical Analysis》2024年第4期615-618,共4页药物分析学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant No.:82130113);the National Key R&D Program of China(Program No.:2023YFC3504402);the China Postdoctoral Science Foundation(Grant No.:2021MD703800);the Science Foundation for Youths of Science&Technology Department of Sichuan Province(Grant Nos.:2023NSFSC1775,2022NSFSC1449);the“Xinglin Scholars”Research Promotion Program of Chengdu University of TCM(Grant Nos.:BSH2021009,QJRC2022044).

摘　　要：The dried roots of Aconitum pendulum Busch are the major source of a commonly used Tibetan medicine,namely Tiebangchui(TBC)(Fig.S1).However,raw TBC contains a large amount of high toxic diester-diterpenoid alkaloids(DDAs),and the improper use would cause arrhythmia,irreversible cardiovascular damages,and even death.“Paozhi”,an appropriate processing method,is the essential prerequisite for the safe clinical application of TBC.Water-decocting and sand-frying are commonly used processing methods for toxicity attenuation and efficacy preservation for TBC.

关 键 词：DRIED IRREVERSIBLE ROOTS 

分 类 号：R284[医药卫生—中药学]