眼眶淋巴瘤的临床特点及诊断进展  

Clinical features and diagnostic progress of orbital lymphoma

作　　者：孙梅(综述) 马建民(审校) Sun Mei;Ma Jianmin(Beijing Tongren Hospital,Capital Medical University,Beijing Tongren Eye Center,Beijing Ophthalmology&Vision Science Key Lab,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京同仁眼科中心,北京市眼科学与视觉科学重点实验室,北京100730

出　　处：《中华实验眼科杂志》2024年第8期774-779,共6页Chinese Journal Of Experimental Ophthalmology

基　　金：北京市自然科学基金(7222025);北京市医院管理中心登峰人才计划(DFL20190201);北京市科技新星计划交叉合作课题(20220484218)。

摘　　要：眼眶淋巴瘤(OLs)是眼部淋巴瘤常见的类型。该病是一种结外恶性肿瘤,既可原发于眼眶,也可为全身淋巴瘤继发眼眶受累。OLs多发于女性,通常表现为单侧眼球突出和眶周肿胀。惰性病变的症状持续时间较长,而侵袭性病变往往发展较快还可伴有疼痛和炎症反应。当肿瘤累及眶内不同组织时可出现上睑下垂、复视以及视力障碍等症状。其临床特征和影像学表现均不具有特异性,需与多种眼眶疾病鉴别。因此,当患者出现某些非特异性眼眶症状时,需行眼眶CT、MRI等影像学检查以了解眼眶内情况,再行进一步手术活检,以早期确诊。目前,OLs诊断的金标准是组织病理学检查,其分型分期则依赖于免疫组织化学分析和PET-CT。疾病的临床分期直接影响治疗方案的制定和预后结果,因此一旦确定诊断并完成OLs的分型分期即可尽早制定合适的治疗方案。本文对近年来OLs的临床表现及诊断相关研究进行综述,以期进一步了解该病并为临床工作提供参考。Orbital lymphomas(OLs)are the common types of ocular lymphomas.The disease is an extranodal malignant tumor,which can be either primary orbital or secondary to orbital involvement of systemic lymphoma.OLs are more common in women and usually present with unilateral eyeball protrusion and periorbital swelling.The symptoms of indolent lesions last longer,while the rapid development of invasive lesions is often accompanied by pain and inflammation.Symptoms such as ptosis,diplopia and visual impairment can also occur when the tumor involves different tissues in the orbit.The clinical features and imaging findings of OLs are not specific,so OLs need to be identified with a variety of orbital diseases.Therefore,when patients have certain non-specific orbital symptoms,orbital CT,MRI and other imaging examinations are required to check the orbital situation.Further surgical biopsy should be performed to confirm the diagnosis at an early stage.The current gold standard for the diagnosis of OLs is histopathological examination,and its classification and staging depend on immunohistochemical analysis and PET-CT,respectively.The clinical staging of the disease directly affects the development of the treatment plan and the prognostic outcomes,so once the diagnosis is confirmed and the staging of OLs is completed,the appropriate treatment plan can be formulated as soon as possible.This article reviews the clinical manifestations and diagnosis of OLs in recent years to further understand the disease and provide a reference for clinical work.

关 键 词：眼眶 淋巴瘤 症状 病理学 影像学 分期 诊断 

分 类 号：R739.72[医药卫生—肿瘤]