Prognostic significance of CDKN2A expression in colon adenocarcinoma: insights from TCGA analysis  

作　　者：Wei Fu Yao Wang Qin-Ming Yan Guo-Bin Cheng Lin-Ya Lyu Yao Ding 

机构地区：[1]Department of Gastroenterology,925th Hospital of Joint Logistics Support Force of People’s Liberation Army of China,Guiyang 510009,China

出　　处：《Cancer Advances》2024年第16期1-10,共10页TMR肿瘤进展

基　　金：Guizhou Provincial Department of Science and Technology Natural Science Foundation(No Foundation-ZK[2022]);the Guizhou Provincial Health Commission Science and Technology Fund(No.GZWKJ2023-135);the Science Foundation of 925th Hospital(No.2023[3],No.2022[3/4]).

摘　　要：Background:The cyclin-dependent kinase inhibitor 2a(CDKN2A)gene,identified as the multiple tumor suppressor gene,functions as a regulatory gene implicated in cancer pathogenesis.Its significance lies in its pivotal involvement in the genesis of various tumors;notwithstanding,the precise connection between CDKN2A and c olon adenocarcinoma(COAD)remains undisclosed.Methods:The objective of this research was to assess the predictive importance of CDKN2A in COAD by analyzing data from The Cancer Genome Atlas database.Logistic regression,signed rank test,Wilcoxon test,and Kruskal-Wallis test were used to examine CDKN2A expression levels and clinicopathological features.Univariate and multivariate Cox r egression analyses and Kaplan-Meier analysis found prognostic variables.Additionally,gene set enrichment analysis identified key CDKN2A expression pathways.The study additionally examined CDKN2A expression with tumor immune infiltration using The Cancer Genome Atlas data and single sample gene set enrichment analysis.Results:The results of this investigation indicated a substantial connection between higher CDKN2A expression and negative outcomes in terms of overall survival and disease-related survival among COAD patients.Gene set enrichment analysis indicated a tight link between CDKN2A and both the cell cycle and hedgehog signaling pathways.Subsequent evaluation employing single sample gene set enrichment analysis demonstrated a positive link between CDKN2A expression with infiltration by iDCs,whereas a negative correlation was detected with infiltration by helper T cells.Conclusion:In conclusion,the present study gives strong data supporting the predictive value of CDKN2A and its possible usefulness as a biomarker for COAD.Additionally,our results show a reasonable link between CDKN2A expression and immune influx in COAD,putting light on the role of CDKN2A in the control of the tumor microenvironment.Nevertheless,additional studies are needed to confirm the underlying mechanisms of these relationships and to discover

关 键 词：CDKN2A colon adenocarcinoma immune infiltration prognostic analysis helper T cells 

分 类 号：R73[医药卫生—肿瘤]