网络游戏成瘾患者脑功能异常静息态功能磁共振成像研究  

A resting-state functional magnetic resonance imaging study of abnormal brain function in patients with Internet gaming disorder

作　　者：陈君[1] 张勇[1] 牛晓玉 张孟哲 马泷耀 程敬亮[1] CHEN Jun;ZHANG Yong;NIU Xiaoyu;ZHANG Mengzhe;MA Longyao;CHENG Jingliang(Department of Magnetic Resonance,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450002,China)

机构地区：[1]郑州大学第一附属医院磁共振科,郑州450002

出　　处：《磁共振成像》2024年第8期59-64,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：河南省重点研发与推广专项(科技攻关)项目(编号:212102310712)。

摘　　要：目的采用局部一致性(regional homogeneity,ReHo)和功能连接(functional connectivity,FC)相结合的方法探究网络游戏成瘾(Internet gaming disorder,IGD)患者静息状态下的脑局部固有连接的改变。材料与方法对44例IGD患者和49例年龄、性别、受教育年限相匹配的健康对照者进行静息态功能磁共振成像(resting state-functional magnetic resonance imaging,rs-fMRI)检查。计算并比较两组的ReHo值,以检测IGD患者脑内局部连接的改变;以ReHo值异常的脑区进行功能连接,以得到不同脑区间连接性的改变。采用网络成瘾测试(Internet Addiction Test,IAT)评估IGD的严重程度。Pearson相关分析用于评估具有ReHo改变的脑区域与IAT评分之间的关系。结果IGD组双侧内侧额上回、双侧背外侧额上回、左侧辅助运动区、右侧额中回ReHo增加;左侧枕下回、左侧枕中回、左侧舌回、左侧距状裂周围皮层、左侧梭状回、左侧颞上回以及左侧小脑ReHo值减低(体素水平P<0.005,团块水平P<0.05,高斯随机场校正)。IGD组右侧背外侧额上回与右侧额上回、双侧辅助运动区、右侧中央前回的功能连接性增加(体素水平P<0.005,团块水平P<0.05,高斯随机场校正)。此外,左侧距状裂周围皮层ReHo值与IAT评分呈负相关(r=-0.340,P=0.024)。结论在前额叶皮层、颞枕叶皮层局部连接发生改变,可能表明IGD的认知控制和奖励处理以及视觉、听觉网络已受到影响。此外,左侧距状裂周围皮层ReHo值与IAT评分呈负相关,可能为IGD的神经病理机制提供新的认识。Objective:To explore the changes of local intrinsic brain connectivity in the resting state of Internet gaming disorder(IGD)using a combination of regional homogeneity(ReHo)and functional connectivity(FC).Materials and Methods:Resting-state functional magnetic resonance imaging(rs-fMRI)was performed on 44 patients with IGD and 49 healthy controls with matching age,sex,and years of education.The ReHo of the two groups was calculated and compared to detect the changes of local connections in the brain of IGD patients.FC was performed with ReHo abnormal brain regions to obtain changes in the connectivity of different brain regions.The Internet Addiction Test(IAT)was used to assess the severity of Internet gaming disorder.Pearson correlation analysis was used to assess the relationship between brain regions with ReHo alterations and IAT scores.Results:In the IGD group,the bilateral medial superior frontal gyrus,bilateral dorsolateral superior frontal gyrus,left auxiliary motor area,and right middle frontal gyrus increased ReHo.Left inferior occipital gyrus,left middle occipital gyrus,left lingual gyrus,left calcarine sulcus cortex,left fusiform gyrus,left superior temporal gyrus,and left cerebellar ReHo are reduced(voxel level P<0.005,mass level P<0.05,Gaussian random field correction).In the IGD group,the functional connectivity of the right dorsolateral superior frontal gyrus and the right superior frontal gyrus,bilateral accessory motor areas,and right precentral gyrus was increased(voxel level P<0.005,mass level P<0.05,Gaussian random field correction).In addition,the ReHo value of the cortex around the left calcarine sulcus cortex was negatively correlated with the IAT score.Conclusions:Alterations in local connections in the prefrontal cortex and temporal-occipital cortex may indicate that cognitive control and reward processing and visual and auditory networks in IGD have been affected.In addition,the ReHo value of the cortex around the left calcarine sulcus cortex was negatively correlated with the IAT score,

关 键 词：网络游戏成瘾 静息态功能磁共振成像 磁共振成像 局部一致性 功能连接 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749[医药卫生—诊断学]