TRPV3调节剂研究进展  

Research progress of TRPV3 regulators

作　　者：张杰 王雨晶 唐青莲 曹征宇 ZHANG Jie;WANG Yujing;TANG Qinglian;CAO Zhengyu(School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学中药学院,江苏南京211198

出　　处：《山东第一医科大学（山东省医学科学院）学报》2024年第8期496-506,共11页Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences

基　　金：国家自然科学基金(81903826,82100585,82204653);“双一流”高校建设专项资金(CPU2022QZ30);江苏省研究生科研与实践创新计划项目(KYCX23-0868)。

摘　　要：瞬时受体电位通道香草素亚族3(transient receptor potential vanilloid 3,TRPV3)是一种定位于细胞质膜的Ca^(2+)渗透性离子通道,除了温热(≥32℃)这一物理调控方式,TRPV3的活性受各种内源性和外源性的化学物质调控。利用这些化学调控,研究揭示了TRPV3的生理(温度感知、毛发生长)和病理(疼痛转导、皮肤炎症)功能,也提示TRPV3是具有潜力的药物开发靶点。本文综述了TRPV3调节剂的研究进展,以期为TRPV3的后续研究提供参考。Transient receptor potential channel vanilloid 3(TRPV3)is a Ca^(2+)permeable channel,located in plasma membrane.Except physical regulation of warmth(≥32℃),the activity of TRPV3 is regulated by various endogenous and exogenous chemicals.With these chemicals,recent studies reveal physiological and pathological functions of TRPV3 including temperature sensing,hair growth,pain transduction,and skin inflammation,suggesting that TRPV3 is a potential drug development target.This article reviews the research progress of TRPV3 modulators,providing reference for subsequent researches on TRPV3.

关 键 词：瞬时受体电位通道香草素亚族3 激动剂 抑制剂 

分 类 号：R914[医药卫生—药物化学]