基于AMPA受体和神经电生理分析拉莫三嗪治疗癫痫的效果  

Effect of lamotrigine in the treatment of epilepsy assessed by AMPA and neuroelectrophysiology

作　　者：黄媛媛 李直 胡海琼 李佳敏 HUANG Yuanyuan;LI Zhi;HU Haiqiong;LI Jiamin(Nanchong Mental Health Center of Sichuan Province,Nanchong 637000,China;Xianyang Hospital of Yan’an University,Xianyang 712000,China)

机构地区：[1]四川省南充精神卫生中心,四川南充637000 [2]延安大学咸阳医院,陕西咸阳712000

出　　处：《中国实用神经疾病杂志》2024年第9期1112-1116,共5页Chinese Journal of Practical Nervous Diseases

基　　金：四川省基层卫生事业发展研究中心科研项目(编号:SWFZ22-C-73)。

摘　　要：目的基于α-氨基-3-羟基-5-甲基异恶唑-4-丙酸(AMPA)受体和神经电生理变化分析拉莫三嗪治疗癫痫的效果。方法选取2022-08—2023-12四川省南充精神卫生中心神经内科收治的82例癫痫患者为对象,随机分为对照组41例和观察组41例。对照组予以丙戊酸钠治疗,观察组予以拉莫三嗪治疗,统计2组临床疗效及不良反应发生情况,比较2组患者治疗前后AMPA受体水平和神经电生理变化情况。结果观察组临床总有效率高于对照组(P<0.05)。治疗3、6个月后,2组AMPA受体水平明显低于治疗前(P<0.05),且观察组低于对照组(P<0.05);2组θ、δ、α频率稳定情况明显优于治疗前(P<0.05),且观察组优于对照组(P<0.05);2组θ、δ、α波段相对功率比较无统计学差异(P>0.05)。观察组不良反应发生率较对照组低(P<0.05)。结论拉莫三嗪治疗癫痫的疗效确切,安全性较高。通过检测患者AMPA受体水平、监测脑电图变化情况可对拉莫三嗪治疗癫痫的疗效作出有效评估。Objective To analyze the effect of lamotrigine on epilepsy based onα-amino-3-hydroxy-5-methylisoxazol-4-propionic acid(AMPA)receptor and neuroelectrophysiological changes.Methods From August 2022 to December 2023,82 epileptic patients admitted to the Neurology Department of Nanchong Mental Health Center of Sichuan Province were selected as the research objects,and were randomly divided into the control group of 41 cases and the observation group of 41 cases.The control group was treated with sodium valproate,and the observation group was treated with lamotrigine.The clinical efficacy and adverse reactions of the two groups after treatment were statistically analyzed,and the AMPA receptor level and neuroelectrophysiological changes of the two groups before and after treatment were compared.Results The total clinical effective rate of the observation group was higher than that of the control group(P<0.05).After 3 and 6 months of treatment,the levels of AMPA receptor in both groups were significantly lower than those before treatment(P<0.05),and the observation group was lower than the control group(P<0.05).After 3 and 6 months of treatment,the frequency stability ofθ,δ,αin both groups was significantly better than that before treatment(P<0.05),and the observation group was better than the control group(P<0.05).After 3 and 6 months of treatment,there was no significant difference in relative power ofθ,δandαband between the two groups(P>0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Lamotrigine is effective and safe in the treatment of epilepsy.The efficacy of lamotrigine in the treatment of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Lamotrigine is effective and safe in the treatment of epilepsy.The efficacy of lamotrigine in the treatment of epilepsy can be effectively evaluated by detecting the level of AMPA receptor and monitoring the changes of EEG.

关 键 词：癫痫 AMPA受体 神经电生理 拉莫三嗪 脑电图 

分 类 号：R742.1[医药卫生—神经病学与精神病学]