低强度聚焦超声活化小胶质细胞治疗阿尔茨海默病的动物研究进展  

Advances in animal studies on the activation of microglial cells by low-intensity focused ultrasound in treatment of Alzheimer disease

作　　者：李硕[1] 刘焕亮 崔慧娟 曹慧(综述) 付源(审校) LI Shuo;LIU Huanliang;CUI Huijuan(Department of Ultrasound,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第四医院超声科,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属第四医院神经内科,黑龙江哈尔滨150001 [3]浙江大学医学院附属第一医院神经内科,浙江杭州310003

出　　处：《中风与神经疾病杂志》2024年第8期709-713,共5页Journal of Apoplexy and Nervous Diseases

基　　金：黑龙江省自然科学基金联合引导项目(LH2021H036);国家自然科学基金(81500917);教育部“春晖计划”合作科研项目(HLJ2019012);黑龙江省博士后科研启动基金(LBH-Q19033);黑龙江省留学归国科学基金(LC2016033);哈尔滨医科大学伍连德青年科学基金(WLD-QN1711);浙江大学百人计划启动基金(B202306)。

摘　　要：阿尔茨海默病(AD)是老年人群中常见的神经系统变性疾病,以淀粉样斑块异常蓄积为典型病理特征。血脑屏障因其严格的选择透过性阻止一切大分子物质进入中枢神经系统,成为向脑内输送治疗药物的“瓶颈”。研究发现,低强度聚焦超声结合超声微泡可通过空化作用安全可逆地打开血脑屏障内皮细胞间隙,并通过促进小胶质细胞向抗炎状态活化减轻淀粉样蛋白沉积。本综述旨在深入剖析低强度聚焦超声在治疗AD中的最新研究进展,为AD的治疗提供理论基础和新策略。Alzheimer disease is a common neurodegenerative disease among the elderly and has abnormal accumulation of amyloid plaques as the typical pathological feature.Because of its strict selective permeability,the blood-brain barrier prevents all macromolecular substances from entering the central nervous system and has thus become a"bottleneck"for delivering therapeutic drugs to the brain.Studies have shown that low-intensity focused ultrasound combined with ultrasound microbubbles can safely and reversibly open the junction between endothelial cells of the blood-brain barrier through cavitation and reduce amyloid deposition by promoting the activation of microglial cells into an anti-inflammatory state.This article reviews the latest research advances in low-intensity focused ultrasound in the treatment of Alzheimer disease,in order to provide a theoretical basis and new strategies for the treatment of Alzheimer disease.

关 键 词：阿尔茨海默病 低强度聚焦超声 小胶质细胞 血脑屏障 

分 类 号：R749.1[医药卫生—神经病学与精神病学]