The Anticancer Potential of Quassinoids-A Mini-Review  

作　　者：Cai Lu Si-Nan Lu Di Di Wei-Wei Tao Lu Fan Jin-Ao Duan Ming Zhao Chun-Tao Che 

机构地区：[1]Jiangsu Collaborative Innovation Center of Chinese Medicinal Resource Industrialization,Nanjing University of Chinese Medicine,Nanjing 210023,China [2]National and Local Collaborative Engineering Center of Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China [3]School of Chinese Medicine&School of Integrated Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China [4]School of Medicine&Holistic Integrative Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China [5]Department of Pharmaceutical Sciences,College of Pharmacy,University of Illinois Chicago,Chicago,IL 60612,USA

出　　处：《Engineering》2024年第7期27-38,共12页工程（英文）

基　　金：supported by the National Natural Science Foundation of China(82274085);the Natural Science Foundation of Jiangsu Province(BK20220478);the Natural Science Foundation of Jiangsu Higher Education institutions of China(22KJB360010).

摘　　要：The anticancer potential of quassinoids has attracted a great deal of attention for decades,and scientific data revealing their possible applications in cancer management are continuously increasing in the literature.Aside from the potent cytotoxic and antitumor properties of these degraded triterpenes,several quassinoids have exhibited synergistic effects with anticancer drugs.This article provides an overview of the potential anticancer properties of quassinoids,including their cytotoxic and antitumor activities,mechanisms of action,safety evaluation,and potential benefits in combination with anticancer drugs.

关 键 词：Quassinoid Anticancer potential Antiproliferative mechanism Safety evaluation Synergistical combination with anticancer DRUGS 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]