20 Hz重复经颅磁刺激联合文拉法辛治疗成人广泛性焦虑障碍的效果研究  

Study on the effects of 20 Hz repetitive transcranial magnetic stimulation combined with venlafaxine in the treatment of adult generalized anxiety disorders

作　　者：楚孔渠 甘景梨 段惠峰 梁学军 CHU Kongqu;GAN Jingli;DUAN Huifeng;LIANG Xuejun(Chinese People′s Liberation Army Joint Logistics Support Force 988 Hospital Military Institute of Mental Disease Prevention and Control,Jiaozuo,Henan 454003,China)

机构地区：[1]中国人民解放军联勤保障部队第九八八医院全军精神疾病防治研究所,河南焦作454003

出　　处：《现代医药卫生》2024年第16期2727-2731,共5页Journal of Modern Medicine & Health

基　　金：河南省医学科技攻关计划项目(LHGJ20200791)。

摘　　要：目的观察20 Hz重复经颅磁刺激(rTMS)联合文拉法辛治疗成人广泛性焦虑障碍(GAD)的疗效及对认知功能和负性情绪的影响。方法选取2021年3月至2023年4月该院收治的成人GAD患者75例,采用随机数字表法分为研究组(38例)和对照组(37例)。对照组患者采用文拉法辛治疗,研究组患者则在文拉法辛治疗基础上联用rTMS治疗。对比2组患者临床疗效。结果研究组患者总有效率、眼动测定、蒙特利尔认知评估量表评分均明显高于对照组,事件相关电位潜伏期,以及GAD-7量表、汉密尔顿焦虑量表、汉密尔顿抑郁量表评分均明显低于对照组,差异均有统计学意义(P<0.05)。结论20 Hz rTMS联合文拉法辛治疗能提高成人GAD患者的临床疗效,改善其认知功能,并缓解其负性情绪,治疗实用性较高。Objective To observe the effects of 20 Hz repetitive transcranial magnetic stimulation(rTMS)combined with venlafaxine in the treatment of adult generalized anxiety disorder(GAD)and its impact on cognitive function and negative emotions.Methods A total of 75 adult patients with GAD admitted to the hospital from March 2021 to April 2023 were randomly divided into two groups using the random number table method.The control group(37 cases)received venlafaxine treatment,while the study group(38 cases)received rTMS on the basis of venlafaxine.The clinical efficacy of the two groups was compared.Results The total effective rate,eye movement measurement,Montreal Cognitive Assessment Scale(MoCA)scores in the study group were higher than those in the control group,and the event-related potential latency,as well as the scores of GAD-7 scale,Hamilton Anxiety Scale and Hamilton Depression Scale were significantly lower than those of the control group,with statistical significance(P<0.05).Conclusion The 20 Hz repetitive transcranial magnetic stimulation combined with venlafaxine therapy can improve the clinical efficacy,cognitive function,and alleviate negative emotions in adult patients with GAD,with high therapeutic practicality.

关 键 词：重复经颅磁刺激 文拉法辛 成年人 广泛性焦虑障碍 认知功能 负性情绪 

分 类 号：R749.72[医药卫生—神经病学与精神病学]