血脑屏障结构与功能及缺血性中风损伤机制的研究进展  

Research progress on the structure and function of blood-brain barrier and injury mechanism mechanism of ischemic stroke

作　　者：谭娇(综述) 苏湲淇[1] 徐晓玉[2] 薛强(审校)[1] TAN Jiao;SU Yuanqi;XU Xiaoyu;XUE Qiang(Chongqing Medical and Pharmaceutical College,Chongqing 401331,China;College of Pharmaceutical Sciences Southwest University,Chongqing 400715,China)

机构地区：[1]重庆医药高等专科学校,重庆401331 [2]西南大学药学院中药学院,重庆400715

出　　处：《现代医药卫生》2024年第16期2820-2825,共6页Journal of Modern Medicine & Health

基　　金：国家自然科学基金面上项目(81473549);国家科技重大新药创制专项(2014ZX09304-306-04);重庆市自然科学基金项目(cstc2018jcyjA0749)。

摘　　要：中风是世界范围内发病率、致残率、致死率均高的疾病。血脑屏障(BBB)是维持脑内微环境稳定的重要功能性结构,在中风初期即被破坏,是中风主要并发症,且会加重中风对脑组织的损害。同时,BBB结构与功能的完整性程度是预测中风后溶栓治疗和血栓切除术后出血转化风险的关键因素,也是预防急性中风进一步脑损伤的重要治疗靶点。该文将近年来关于BBB结构、功能、缺血性损伤变化,以及潜在治疗靶点的相关研究进行了综述,为进一步认识和理解缺血性中风BBB变化及保护性药物开发提供思路。Stroke is the disease with high morbidity,disability and mortality worldwide.The blood-brain barrier(BBB)is an important functional structure that maintains the stability of the microenvironment in the brain,and is disrupted in the early stages of stroke,which is a major complication of stroke and exacerbates the damage to brain tissue caused by stroke.At the same time,the degree of structural and functional integrity of the BBB is a key predictor of the risk of hemorrhagic transformation after thrombolytic therapy and thrombectomy after stroke,and an important therapeutic target for preventing further brain damage in acute stroke.This article reviews the relevant studies on BBB structure,function,ischemic injury changes,and potential therapeutic targets in recent years to provide ideas for further knowledge and understanding of ischemic stroke BBB changes and protective drug development.This article reviews the relevant studies on BBB structure,function,ischemic injury changes and potential therapeutic targets in recent years to provide ideas for further knowledge and understanding of BBB changes in ischemic stroke and protective drugs development.

关 键 词：缺血性中风 血脑屏障 脑微血管内皮细胞 紧密连接 神经炎症 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]