铜死亡相关基因LIPT1在乳腺癌中表达及免疫浸润预测  

Expression and immune infiltration prediction of copper death related gene LIPT1 in breast cancer

作　　者：张兆君 孙杰克 李健森 石玉荣 ZHANG Zhaojun;SUN Jieke;LI Jianseng;SHI Yurong(Key Laboratory of Cancer and Translational Medicine of Bengbu Medical College,Bengbu 233000,China;School of Laboratory Medicine,Bengbu Medical Collegea)

机构地区：[1]蚌埠医学院癌症与转化医学重点实验室,安徽蚌埠233000 [2]蚌埠医学院检验医学院

出　　处：《包头医学院学报》2024年第8期1-6,共6页Journal of Baotou Medical College

基　　金：安徽省教育厅自然科学重点项目(KJ2021A0713);蚌埠医学院研究生科研创新计划项目(Byycxz23026);国家级大学生创新创业项目(202210367049)。

摘　　要：目的:利用生物信息学方法,探讨脂酰转移酶1(lipoyltransferase 1,LIPT1)在乳腺癌发生发展及免疫浸润中的作用。方法:运用TCGA、GEPIA、HPA、UALCAN、Kaplan-Meier、TIMER 2.0等数据库,分析LIPT1在乳腺癌中的表达情况、蛋白互相作用网络及对乳腺浸润性癌免疫浸润的影响。结果:LIPT1表达与乳腺浸润性癌相关,PPI网络分析LIPT1蛋白表达与酰基辅酶A合成酶中链家族成员1、二氢硫辛胺支链转酰基酶、二氢硫辛酸转乙酰基酶、二硫辛酰胺转乙酰酶、二氢硫辛酸脱氢酶、甘氨酸裂解系统蛋白H、脂酰合酶、脂酰转移酶2、丙酮酸脱氢酶β以及丙酮酸脱氢酶复合体成分X相关;乳腺浸润性癌中LIPT1表达与CD8^(+)T细胞、CD4^(+)T细胞、巨噬细胞以及中性粒细胞浸润相关(P<0.001)。结论:生物信息学预测LIPT1在乳腺浸润性癌中表达下调,并与肿瘤免疫细胞浸润相关。Objective:To explore the role of lipoyltransferase(LIPT1)in the development and immune infiltration of breast cancer by bioinformatics.Methods:TCGA,GEPIA,HPA,UALCAN,Kaplan-Meier,TIMER 2.0 and other databases were used to explore the differential expression,function and related mechanism of LIPT1 in breast cancer,and to analyze the effect of LIPT1 on the immune infiltration of invasive breast cancer.Results:The expression of LIPT1 was associated with invasive breast cancer,and PPI network analysis showed that LIPT1 was associated with ACSM1,DBT,DLAT,DLT,DLST,GCSH,LIAS,LIPT2,PDHB,and PDHX;the expression of LIPT1 was associated with immune cell infiltration in invasive breast cancer.Conclusion:Bioinformatics predicts that LIPT1 expression is down-regulated in invasive breast cancer and is associated with tumor immune cell infiltration.

关 键 词：铜死亡相关基因 LIPT1 乳腺浸润性癌 免疫浸润 

分 类 号：R737.9[医药卫生—肿瘤]