帕金森病相关分子机制及中医药干预效果  

Molecular Mechanisms Related to Parkinson's Disease and the Intervention Effect of Traditional Chinese Medicine

作　　者：杨亚男 孙灵芝[2] 曹晓岚[2] YANG Yanan;SUN Lingzhi;CAO Xiaolan(The First Clinical Medical School,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Neurology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学第一临床医学院,山东省济南市250014 [2]山东中医药大学附属医院神经内一科,山东省济南市250014

出　　处：《实用心脑肺血管病杂志》2024年第9期25-31,共7页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：山东省自然科学基金资助项目(ZR2021MH180);第五批全国中医临床优秀人才研修项目(国中医药办人教函〔2021〕271号)。

摘　　要：随着社会老龄化进程加快,帕金森病(PD)发病率逐年攀升,然而其发生的具体分子机制尚未完全明确,临床上目前仍以对症治疗为主,尚无法阻止疾病进展。中医药在治疗PD方面显示出独特优势,深入挖掘其治疗机制已成为研究热点。本文主要综述了PD相关分子机制[包括α-突触核蛋白(α-syn)聚集、神经炎症、氧化应激、线粒体功能障碍、铁死亡、肠道菌群失调],并从PD相关分子机制角度分析了中医药治疗PD的效果,以期为PD的治疗提供新方向和理论支撑。With the acceleration of the aging process of society,the incidence rate of Parkinson's disease(PD)is increasing year by year.However,the specific molecular mechanism of its occurrence has not yet been fully understood.At present,symptomatic treatment is still the main treatment method in clinical practice,which cannot prevent the disease from progressing.Traditional Chinese medicine has shown unique advantages in treating PD,and exploring its treatment mechanism has become a research hotspot.This article mainly reviews the molecular mechanisms related to PD[includingα-synuclein(α-syn)aggregation,neuroinflammation,oxidative stress,mitochondrial dysfunction,iron death,and gut microbiota imbalance],and analyzes the effectiveness of traditional Chinese medicine in treating PD from the perspective of molecular mechanisms related to PD,in order to provide new directions and theoretical support for the treatment of PD.

关 键 词：帕金森病 分子机制 中医药 治疗结果 综述 

分 类 号：R742.5[医药卫生—神经病学与精神病学]