血清Elabela、系统免疫炎症指数与急性缺血性卒中及其病情严重程度的关系研究  

Relationship between Serum Elabela,Systemic Immune Inflammation Index and Acute Ischemic Stroke and Its Severity of Illness

作　　者：克地尔牙·马合木提 唐娟[1] 冯丽娜[1] 王娟娟 杨婷[1,2] 胡岚卿 高沛沛 田苗苗 苏李涵 姚恩生 KEDIERYA·Mahemuti;TANG Juan;FENG Lina;WANG Juanjuan;YANG Ting;HU Lanqing;GAO Peipei;TIAN Miaomiao;SU Lihan;YAO Ensheng(Department of Neurology,the First Affiliated Hospital of Shihezi University,Shihezi 832008,China;Shihezi University School of Medicine,Shihezi 832008,China)

机构地区：[1]石河子大学第一附属医院神经内科,新疆维吾尔自治区石河子市832008 [2]石河子大学医学院,新疆维吾尔自治区石河子市832008

出　　处：《实用心脑肺血管病杂志》2024年第9期51-55,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：兵团指导性科技计划项目(2022ZD072);八师石河子市科技计划项目(2023BX01-3);石河子大学自主立项课题(ZZZC202081B);石河子大学第一附属医院科技计划项目(GP202110);国家卫健委医药卫生科技发展科技中心项目(WKZX2023CZ0126)。

摘　　要：目的探讨血清Elabela、系统免疫炎症指数(SII)与急性缺血性卒中(AIS)及其病情严重程度的关系。方法选取2022年8月—2023年8月石河子大学第一附属医院神经内科收治的110例AIS患者为AIS组,另选取同期石河子大学第一附属医院神经内科收治的60例非AIS患者为对照组。收集患者的临床资料,包括性别、年龄、BMI、合并症发生情况、有无吸烟史、有无饮酒史和入院时血脂指标、同型半胱氨酸(Hcy)、血清Elabela、SII及AIS患者入院时美国国立卫生研究院卒中量表(NIHSS)评分。根据NIHSS评分评估AIS病情严重程度,以NIHSS评分≤3分为轻型、>3分为中重型。AIS及AIS病情严重程度的影响因素分析采用多因素Logistic回归分析;绘制ROC曲线以评估血清ELA、SII对AIS的预测价值。结果AIS组糖尿病发生率、Hcy、SII高于对照组,血清Elabela低于对照组(P<0.05)。多因素Logistic回归分析结果显示,吸烟史、血清Elabela、SII是AIS的影响因素(P<0.05);血清Elabela、SII是AIS病情严重程度的影响因素(P<0.05)。ROC曲线分析结果显示,血清Elabela、SII预测AIS的AUC分别为0.897[95%CI(0.852~0.942)]、0.706[95%CI(0.626~0.787)]。结论血清Elabela、SII是AIS及其病情严重程度的影响因素,但二者对AIS的预测价值不高。Objective To investigate the relationship between serum Elabela,systemic immune inflammation index(SII)and acute ischemic stroke(AIS)and its severity of illness.Methods A total of 110 AIS patients admitted to the Department of Neurology of the First Affiliated Hospital of Shihezi University from August 2022 to August 2023 were selected as the AIS group,and 60 non-AIS patients admitted to the same hospital during the same period were selected as the control group.The clinical data of the patients were collected,including gender,age,BMI,complication,smoking history,drinking history,and blood lipid indexes,homocysteine(Hcy),serum Elabela and SII at admission,and National Institutes of Health Stroke Scale(NIHSS)score of AIS patients at admission.According to the NIHSS score,the severity of illness of AIS was evaluated.The NIHSS score≤3 was considered mild,and>3 was considered moderate and severe.Multivariate Logistic regression analysis was used to analyze the influencing factors of AIS and its severity of illness.ROC curve was drawn to evaluate the predictive value of serum ELA and SII for AIS.Results The incidence of diabetes,Hcy and SII in the AIS group were higher than those in the control group,and serum Elabela was lower than that in the control group(P<0.05).Multivariate Logistic regression analysis showed that smoking history,serum Elabela and SII were the influencing factors of AIS(P<0.05).Serum Elabela and SII were the influencing factors of the severity of illness of AIS(P<0.05).The results of ROC curve analysis showed that the AUC of serum Elabela and SII in predicting AIS was 0.897[95%CI(0.852-0.942)]and 0.706[95%CI(0.626-0.787)],respectively.Conclusion Serum Elabela and SII are the influencing factors of AIS and its severity of illness,but their predictive value for AIS is not high.

关 键 词：缺血性卒中 Elabela 系统免疫炎症指数 病情严重程度 影响因素分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]