动脉介入化疗“超选择法”与“球囊阻断法”治疗视网膜母细胞瘤的效果比较  

Comparison of the Therapeutic Effects of Arterial Interventional Chemotherapy“Super Selection Method”and“Balloon Blockade Method”on Retinoblastoma

作　　者：胡靖 王菲[1] 张景岚 刘景[1] 时胜利 HU Jing;WANG Fei;ZHANG Jinglan;LIU Jing;SHI Shengli(Department of Interventional Medicine and Hemangioma Medicine,Children’s Hospital Affiliated to Zhengzhou University,Zhengzhou 450053,China)

机构地区：[1]郑州大学附属儿童医院介入医学和血管瘤科,河南郑州450053

出　　处：《河南医学研究》2024年第16期2947-2950,共4页Henan Medical Research

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20210688)。

摘　　要：目的观察动脉介入化疗“超选择法”与“球囊阻断法”治疗视网膜母细胞瘤(RB)的有效性、安全性。方法选取郑州大学附属儿童医院2020年6月至2022年6月收治的90例(141眼)RB患者作为研究对象,根据治疗方法分为超选组(45例,68眼)、阻断组(45例,73眼),给予超选组动脉介入化疗“超选择法”,给予阻断组动脉介入化疗“球囊阻断法”。比较两组临床疗效、血清肿瘤指标[存活素、Livin、血管内皮生长因子(VECF)、基质金属蛋白酶-9(MMP-9)]、保眼率、复发率、转移率、安全性分析及预后。结果超选组总有效率(95.59%)较阻断组(83.56%)高(P<0.05);治疗2、4个周期后超选组血清存活素、Livin、VEGE、MMP-9水平低于阻断组(P<0.05);两组保眼率、复发率、转移率、毒副反应及并发症、预后比较,差异无统计学意义(P>0.05)。结论动脉介入化疗“超选择法”与“球囊阻断法”治疗RB患儿的效果确切,但“超选择法”治疗效果优于“球囊阻断法”,两组安全性分析无明显差异。Objective To observe the efficacy and safety of arterial interventional chemotherapy with super selection method and balloon blockade method in the treatment of retinoblastoma(RB).Methods A total of 90 RB patients(141 eyes)admitted to Children’s Hospital Affiliated to Zhengzhou University from June 2020 to June 2022 were selected as the research subjects.They were divided into superselective group(45 cases,68 eyes)and a blocking group(45 eyes,73 eyes)based on the treatment methods.The superselective group received arterial interventional chemotherapy“super selection method”,while the blocking group received arterial interventional chemotherapy“balloon blockade method”.The clinical efficacy,maximum lesion size and mass thickness,serum tumor indexes[survivin,Livin,vascular endothelial growth factor(VECF),matrix metalloproteinase-9(MMP-9)],eye protection rate,recurrence rate,metastasis rate,safety analysis and prognosis were compared between the two groups.Results The total effective rate of the superselected group(95.59%)was higher than that of the blocking group(83.56%)(P<0.05).Serum survivin,Livin,VEGE and MMP-9 levels in the superselected group were lower than those in the blocking group after 2 and 4 cycles of treatment(P<0.05).There were no statistical differences in eye protection rate,recurrence rate,metastasis rate,toxic and side effects,complications and prognosis between two groups(P>0.05).Conclusion“Superselection”and“balloon blocking”are effective in the treatment of RB children,but“superselection”is better than“balloon blocking”,and there is no significant difference in safety analysis between the two groups.

关 键 词：动脉介入化疗 超选择法 球囊阻断法 视网膜母细胞瘤 有效性 安全性 

分 类 号：R744.1[医药卫生—神经病学与精神病学]