埃索美拉唑联合特利加压素对肝硬化上消化道出血患者肝静脉压力梯度的影响  

Effect of Combination of Esomeprazole and Terlipressin on Hepatic Venous Pressure Gradient in Cirrhotic Patients with Upper Gastrointestinal Bleeding

作　　者：陈敏[1] CHEN Min(Department of Pharmacy,the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第三附属医院药学部,河南郑州450000

出　　处：《河南医学研究》2024年第16期3027-3030,共4页Henan Medical Research

摘　　要：目的分析埃索美拉唑联合特利加压素治疗肝硬化上消化道出血后对肝静脉压力梯度的影响。方法选取2020年5月至2022年10月收治的93例肝硬化上消化道出血患者,按照抽签的方式分为两组。观察组47例接受特利加压素联合埃索美拉唑治疗,对照组46例接受生长抑素联合埃索美拉唑治疗。比较两组疗效、临床指标、炎症因子、肝静脉压力梯度、不良反应。结果观察组肝静脉游离压(FHVP)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、血浆皮质醇(Cor)、尿量、血肌酐、平均动脉压水平较对照组高,肝静脉锲入压(WHVP)水平较对照组低(P<0.05);两组止血效果和出血复发率差异无统计学意义(P>0.05)。结论埃索美拉唑联合特利加压素应用于肝硬化上消化道出血的效果好,能够改善患者临床指标及炎症因子,降低肝静脉压力梯度。Objective To analyze the effect of esomeprazole combined with terpressin on hepatic venous pressure gradient after treatment of upper gastrointestinal bleeding in cirrhosis.Methods From May 2020 to October 2022,a total of 93 patients with cirrhosis of the upper digestive tract hemorrhage were selected and divided into two groups according to lottery.The observation group(47 patients)were treated with terpressin combined with esomeprazole,the control group(46 patients)were treated with somatostatin combined with esomeprazole.Efficacy,clinical indicators,inflammatory factors,hepatic venous pressure gradient and adverse reactions in two groups were compared.Results Free hepatic venous pressure(FHVP),hypersensitive C-reactive protein(hs-CRP),tumor necrosis faction-α(TNF-α),plasma cortisol(Cor),urine volume,serum creatinine and mean arterial pressure in the observation group were higher than those in the control group,and wedging hepatic venous pressure(WHVP)level was lower than those in the control group(P<0.05).There was no statistical significance in hemostatic effect and recurrence rate of hemorrhage between the two groups(P>0.05).Conclusion Esomeprazole combined with terpressin has a good effect on upper gastrointestinal bleeding in cirrhotic patients,can improve clinical indicators and inflammatory factors,and reduce the gradient of hepatic venous pressure.

关 键 词：埃索美拉唑 特利加压素 乙型肝炎肝硬化 肝硬化上消化道出血 

分 类 号：R575.2[医药卫生—消化系统]