19例成骨不全症患儿肺功能分析  

Pulmonary function in children with osteogenesis imperfecta of 19 cases

作　　者：侯振齐 Hou Zhenqi(Tianjin Wuqing District People's Hospital,Tianjin 301700,China)

机构地区：[1]天津市武清区人民医院,天津301700

出　　处：《首都食品与医药》2024年第16期18-21,共4页Capital Food Medicine

基　　金：天津市武清区科技计划发展项目资助(编号:WQKJ201729)。

摘　　要：目的探讨Ⅲ型成骨不全患儿的肺功能指标特征.方法回顾性分析2017年1月-2017年12月天津市武清区人民医院共收治的19例Ⅲ型成骨不全患儿(成骨不全组)及非呼吸系统疾病儿童(对照组)肺功能数据.分析比较两组儿童用力肺活量(FVC)、一秒钟用力呼气量(FEV1)、第1秒钟用力呼气量占预计值的百分比(FEV1%)、第1秒钟用力呼气容积/用力肺活量(FEV1/FVC)及最大呼气流量(PEF)指标有无差异.结果两组患儿用力肺活量(FVC)、一秒钟用力呼气量(FEV1)、第1秒钟用力呼气容积/用力肺活量(FEV1/FVC)及最大呼气流量(PEF)等指标均存在明显差异.Ⅲ型成骨不全组患儿肺功能相关指标均低于对照组儿童,且有统计学差异(P<0.05).结论与对照组非呼吸系统疾病患儿相比,Ⅲ型成骨不全患儿的FVC、FEVl、PEF、FEV1/FVC等指标明显降低.Objective To investigate the characteristics of pulmonary function in children with typeⅢosteogenesis imperfecta.Methods The pulmonary function data of 19 children withⅢosteogenesis imperfecta(osteogenesis imperfecta group)and children with non respiratory diseases(control group)admitted to our hospital from January 2017 to December 2017 were analyzed retrospectively.The forced vital capacity(FVC),forced expiratory volume in one second(FEV1),percentage of forced expiratory volume in the first second(FEV1%),forced expiratory volume/forced vital capacity in the first second(FEV1/FVC)and maximum expiratory flow(PEF)were analyzed and compared between the two groups.Results There were significant differences in FVC,FEV1,FEV1/FVC and PEF between the two groups.The lung function related indexes of children withⅢosteogenesis imperfection were lower than those of children in the control group,and there was a statistical difference(P<0.05).Conclusion FVC,FEV1,PEF,FEV1/FVC in children with typeⅢosteogenesis imperfecta were significantly lower than those in children without pulmonary disease in the control group.

关 键 词：成骨不全 用力肺活量 一秒钟用力呼气量 最大呼气流量 肺功能 

分 类 号：R682[医药卫生—骨科学]