近视眼的Bruch膜形态变化  

The morphological alterations of Bruch's membrane in myopic eyes

作　　者：鲁昱含 陈伟[2,3] Lu Yuhan;Chen Wei(School of Medicine Nankai University,Tianjin 300071,China;Tianjin Eye Hospital,Tianjin Key Laboratory of Ophthalmology and Visual Science,Tianjin 300020,China;Department of Ophthalmology,Hotan District People’s Hospital,Hotan Xinjiang 848000,China)

机构地区：[1]南开大学医学院,天津300071 [2]天津市眼科医院,天津市眼科学与视觉科学重点实验室,天津300020 [3]和田地区人民医院眼科,新疆和田848000

出　　处：《国际眼科纵览》2024年第4期272-277,共6页International Review of Ophthalmology

基　　金：国家自然科学基金(82160205);天津市医学重点学科(专科)建设项目(TJYXZDXK-016A)。

摘　　要：近视的发展与进行性的眼轴增长密切相关,在眼轴增长过程中,脉络膜和巩膜厚度均变薄且二者体积不变,而Bruch膜(Bruch’s membrane,BM)的厚度与眼轴轴向长度的变化无关。由于锯齿缘和眼球后极部之间的距离随着轴向长度的延长而拉长,这意味着BM的表面积扩大,因此BM厚度与轴向长度无关的发现表明BM体积随着轴向伸长而增加。高度近视眼中,BM开口、BM缺陷和视盘旁萎缩均与眼轴长度之间存在高度相关性。BM在近视眼中的形态变化可能参与了眼轴增长的病理生理机制,从而为未来的近视干预策略提供了潜在的治疗靶点。The evolution of myopia is intricately linked to the progressive elongation of the ocular axis.Throughout this process,there is a notable thinning of the choroid and sclera,yet their volumes remain remarkably stable.Intriguingly,the thickness of Bruch's membrane(BM)appears to be decoupled from variations in the axial length of the eye.Given that the spatial separation between the ora serrata and the posterior pole escalates in tandem with axial elongation,this phenomenon suggests a concomitant expansion of the BM surface area.Consequently,the observed independence of BM thickness from changes in axial length provides compelling evidence for a compensatory increase in BM volume as the ocular axis extends.In highly myopia,a robust correlation has been observed between increased axial length and the incidence of BM openings,BM defects,and peripapillary atrophy.These findings indicate that the morphological modifications of BM within myopia may significantly contribute to the pathophysiological mechanisms governing axial elongation,hinting at novel therapeutic targets for myopia management.

关 键 词：近视眼 BRUCH膜 

分 类 号：R778.11[医药卫生—眼科]