盐酸度洛西汀治疗抑郁症引发抗利尿激素分泌紊乱综合征1例  

Duloxetine hydrochloride induced syndrome of inappropriate antidiuretic hormone secretion in depression treatment:a case report

作　　者：杨舒婷 范阿娇 Yang Shuting;Fan Ajiao(The First School of Clinical Medical of Lanzhou University,Lanzhou 730000,China;The Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第二医院,甘肃兰州730030

出　　处：《四川精神卫生》2024年第4期376-378,共3页Sichuan Mental Health

摘　　要：盐酸度洛西汀是常用的抗抑郁药之一,其主要作用机制是抑制5-羟色胺与去甲肾上腺素再摄取,提高突触间隙单胺类神经递质浓度,进而发挥抗抑郁作用。其副作用除胃肠道反应、血压升高之外,偶有引起抗利尿激素分泌紊乱综合征(SIADH)的发生。本文报道1例盐酸度洛西汀治疗抑郁症引发的以烦渴多饮为主要表现的SIADH病例,以期为临床医师早期识别该药物引起的这一少见不良反应提供参考。Duloxetine hydrochloride,a serotonin-norepinephrine reuptake inhibitor(SNRIs),is a commonly used antidepressants.Its mechanism of action involves increasing synaptic monoamine neurotransmitters concentration,leading to antidepressant effects.While gastrointestinal reactions and elevated blood pressure are common side effects,duloxetine can rarely induce syndrome of inappropriate antidiuretic hormone secretion(SIADH).This case report presents a patient with depression who developed SIADH following duloxetine hydrochloride initiation,with the main clinical manifestation being restless thirst and excessive drinking.This case is presented to raise awareness among clinicians of this rare yet potentially serious adverse effect of duloxetine treatment.

关 键 词：盐酸度洛西汀 抑郁症 抗利尿激素分泌紊乱综合征 

分 类 号：R749.4[医药卫生—神经病学与精神病学]