非典型梭形细胞脂肪瘤样肿瘤8例临床病理特征  

Clinicopathological characteristics of atypical spindle cell lipomatous tumours:report of eight cases

作　　者：周冬梅[1,2] 卢建平[1] 张静[1] 何时[1] 杨世娟 ZHOU Dongmei;LU Jianping;ZHANG Jing;HE Shi;YANG Shijuan(Department of Pathology,Clinical Oncology School of Fujian Medical University,Fujian Cancer Hospital,Fuzhou 350014,China;Fujian Key Laboratory of Translational Cancer Medicine,Clinical Oncology School of Fujian Medical University,Fujian Cancer Hospital,Fuzhou 350014,China)

机构地区：[1]福建医科大学肿瘤临床医学院/福建省肿瘤医院病理科,福州350014 [2]福建医科大学肿瘤临床医学院/福建省肿瘤医院福建省转化医学重点实验室,福州350014

出　　处：《临床与实验病理学杂志》2024年第8期824-827,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的 探讨非典型梭形细胞脂肪瘤样肿瘤(atypical spindle cell lipomatous tumour, ASLT)的临床病理学特征。方法 回顾性分析8例ASLT的临床病理、免疫表型及分子特征,采用免疫组化EnVision两步法和FISH对8例ASLT进行检测,并复习相关文献。结果 8例均可见不同比例的梭形细胞、脂肪细胞混杂分布,细胞无或轻度异型,无坏死。免疫表型:8例肿瘤细胞CD34、S-100不同程度阳性,RB均表达缺失,MDM2、CDK4阴性或灶阳性,Ki67增殖指数低。FISH检测示6例MDM2无扩增。结论 ASLT是新近命名的良性脂肪源性肿瘤亚型,具有独特的形态学、免疫表型及分子特征,预后好,正确诊断可避免临床过度治疗。Purpose To explore the clinicopathological characteristics of atypical spindle cell lipomatous tumour(ASLT).Methods The clinical pathology,immunophenotype,and molecular characteristics of 8 ASLTs diagnosed and treated in Fujian Cancer Hospital from 2020 to 2023 were collected.The histological morphology,immunophenotype and molecular characteristics of 8 ASLTs were evaluated by HE staining,immunohistochemistry and FISH.Clinicopathological features of 8 ASLTs were analyzed with literature review.Results Mixed distribution of spindle cells and adipocytes in different proportions was seen in all 8 cases,with no or mild cell atypia and no necrosis.Immunophenotypically,8 ASLTs were CD34 and S-100 positive to varying degrees,RB was negative,MDM2 and CDK4 were negative or focus positive,and Ki67 proliferation index was low.FISH showed MDM2 amplification was negative in 6 cases.Conclusion ASLT is a newly named benign adipose-derived tumor subtype with unique morphology,immunophenotype,and molecular characteristics.It has a good prognosis.Correct diagnosis can avoid clinical over-treatment.

关 键 词：脂肪源性肿瘤 梭形细胞脂肪瘤样肿瘤 RB MDM2扩增 

分 类 号：R738.6[医药卫生—肿瘤]