干细胞在纳米颗粒物毒性机制研究中的应用  

Application of Stem Cells in Investigation of Nanoparticles Toxicity M echanisms

作　　者：木拉提·居来提 崔婷婷 那迪热·尼加提 胡博文 Mulati Julaiti;Cui Tintin;Nadire Nijiati;Hu Bowen(State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases,Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Xinjiang Medical University,Urumqi 830017,China)

机构地区：[1]新疆医科大学基础医学院生物化学与分子生物学系,中亚高发病发病机制与防治国家重点实验室,新疆地方病分子生物学重点实验室,乌鲁木齐830017

出　　处：《生态毒理学报》2024年第4期27-42,共16页Asian Journal of Ecotoxicology

基　　金：新疆维吾尔自治区杰出青年项目基金(2022D01E52);国家自然科学基金青年项目(22206162);新疆维吾尔自治区天山创新团队计划(2022D1400)。

摘　　要：纳米颗粒物因其优异的性能在各个领域中都得到了广泛的应用。然而,这些纳米颗粒物的潜在健康风险,尤其是对胎儿发育的影响也受到越来越广泛的关注。干细胞的多向分化的特点使其逐渐成为了评估纳米颗粒物的安全性和发育毒性的有力工具。本综述深入分析了干细胞在金属和非金属纳米粒子的发育毒性研究中的现状。深入探讨了具有不同特性(如尺寸、形状、表面电荷等)的纳米颗粒物对干细胞的影响,以及由此产生的毒性效应的差异。最后强调了干细胞来源的类器官在纳米毒理学的研究中的潜力,为毒理学研究提供了更加准确的毒性评价模型。Nanoparticles,because of their unique physical and chemical properties,have been widely utilized in numerous fields.However,growing concerns are being raised regarding their potential health risks,particularly the impact on fetal development.Stem cells,with their capacity for self-renewal and differentiation,are emerging as valuable tools for assessing the safety and developmental toxicity of nanoparticles.This review examines the role of stem cells in evaluating the developmental toxicity of both metallic and non-metallic nanoparticles.It explores how nanoparticle characteristics,including size,shape,and surface charge,influence stem cell behavior and contribute to variations in toxicological outcomes.The review also underscores the promising role of stem cell-derived organoids in advancing nano toxicology,providing a more accurate and predictive model for toxicological studies.

关 键 词：纳米颗粒物 干细胞 类器官 

分 类 号：X171.5[环境科学与工程—环境科学]