海洋双壳类中镉与必需元素的相互作用  

Interactions between Cadmium and Essential Elements in Marine Bivalves

作　　者：张晓宇 李斐[1] 吉成龙[1,2] 吴惠丰 Zhang Xiaoyu;Li Fei;Ji Chenglong;Wu Huifeng(CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation,Shandong Key Laboratory of Coastal E nvironmental Processes,Yantai Institute of Coastal Zone Research(YIC),Chinese Academy of Sciences(CAS),Yantai 264003,China;Laboratory for Marine Fisheries Science and Food Production Processes,Qingdao National Laboratory for Marine Science and T echnology,Qingdao 266237,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院烟台海岸带研究所,中国科学院海岸带环境过程与生态修复重点实验室,山东省海岸带环境过程重点实验室,烟台264003 [2]青岛海洋科学与技术国家实验室,海洋渔业科学与食物产出过程功能实验室,青岛266237 [3]中国科学院大学,北京100049

出　　处：《生态毒理学报》2024年第4期206-216,共11页Asian Journal of Ecotoxicology

基　　金：国家自然科学基金资助项目(42076164);山东省青年泰山学者项目(tsqn201812115);山东省重点研发项目(2022CXPT019)。

摘　　要：镉(cadmium,Cd)是海洋中常见的重金属污染物,因其有较高的生态风险而备受关注。海洋双壳类因其底栖和滤食的习性极易在体内富集Cd,进而引起氧化应激、信号转导异常和能量代谢紊乱等毒性效应。Cd能通过必需元素的转运载体或通道进入海洋双壳类体内。海洋双壳类具备一系列防御Cd的机制,如与含硫、氮和硒的配体结合,以减少游离Cd^(2+)浓度并降低氧化应激,从而减轻Cd毒性。而在某些关键的生物学通路中,与Cd大小和电荷相似的必需元素(如钙、铜和锌)能被Cd竞争或取代,导致必需元素稳态发生变化,进而引起机体代谢异常,产生毒性效应。此外,本文介绍了可用于海洋生态毒理学研究的新工具——离子组学,以深入探究多种元素的相互作用。本文为深入了解Cd的毒理机制和海洋生态风险提供重要参考。Cadmium(Cd)is a widespread contaminant in the marine environment,attracting great concern due to its high toxicity and risk.The benthic filter-feeding habits of marine bivalves make them highly susceptible to the bioaccumulation of Cd,leading to a variety of adverse effects such as oxidative stress,metabolic disorder and a bnormal signal transduction.Exogenous Cd can enter marine bivalves via transport proteins/channels of essential elements.In order to resist Cd-induced stress,marine bivalves have developed a series of defense mechanisms,e.g.,complexation with ligands containing sulfur,nitrogen and selenium.These adaptive responses can reduce the c oncentration of free Cd ions in bivalves and further alleviate Cd-induced toxicity.However,in several key b iological pathways,Cd can compete or replace essential elements of similar size and charge such as calcium,c opper and zinc,thereby disrupting elemental homeostasis and causing toxic effects.In addition,this review h ighlights ionomics as a novel analytical tool for exploring the interactions of multiple elements in ecotoxicological studies.Collectively,this review provides an important reference for an in-depth understanding of the toxicological mechanisms and ecological risk of Cd in the marine environment.

关 键 词：镉 海洋双壳类 离子互作 离子组学 

分 类 号：X171.5[环境科学与工程—环境科学]