Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis  

作　　者：Baolong Liu Phuong Linh Nguyen Han Yu Xingzhi Li Huiren Wang Tram Gia Bao Nguyen Prakash Kumar Sahoo Meghna Sur Jay Reddy Sarah Sillman Stephen D.Kachman Bara Altartouri Guoqing Lu Sathish Kumar Natarajan Mahesh Pattabiraman Jiujiu Yu 

机构地区：[1]Department of Nutrition and Health Sciences,University of Nebraska-Lincoln,Lincoln,NE 68583,USA [2]Shaanxi Key Laboratory of Molecular Biology for Agriculture,College of Animal Science and Technology,Northwest A&F University,Yangling 712100,China [3]Department of Nutrition,Case Western Reserve University,Cleveland,OH 44106,USA [4]School of Veterinary Medicine and Biomedical Sciences,University of Nebraska-Lincoln,Lincoln,NE 68583,USA [5]Department of Statistics,University of Nebraska-Lincoln,Lincoln,NE 68583,USA [6]Center for Biotechnology,University of Nebraska-Lincoln,Lincoln,NE 68588,USA [7]Department of Biology,University of Nebraska Omaha,Omaha,NE 68182,USA [8]Department of Chemistry,University of Nebraska-Kearney,Kearney,NE 68849,USA

出　　处：《Acta Pharmaceutica Sinica B》2024年第8期3661-3679,共19页药学学报（英文版）

基　　金：supported by the United States Department of Agriculture(USDA)National Institute of Food and Agriculture(NIFA)Multistate Hatch Project 1021080,Standard Grant(2021-67017-34206,USA);the National Institutes of Health(NIH)grant R01DK124590(USA);partially funded by the Nebraska Center for Integrated Biomolecular Communication COBRE grant(P20 GM113126,NIGMS,USA);the Nebraska Research Initiative.

摘　　要：Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related death.Currently,no medication is specifically approved to treat NAFLD or NASH.Here we report that oral administration of honey vesiclelike nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged mice.Besides their reported antiinflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-kB pathways.Collectively,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关 键 词：HONEY Extracellular vesicles EXOSOMES NANOPARTICLES MICRORNAS Aging Inflammation Non-alcoholic steatohepatitis 

分 类 号：R965[医药卫生—药理学]