SOX17-mediated immune evasion in early colorectal cancer:From pre-malignant adaptation to tumor progression  

作　　者：Yanfeng Gao Yanping Wang Jinsong Zhao Yujun Song 

机构地区：[1]School of Medical Imaging,Wannan Medical College,Wuhu 241002,China [2]College of Engineering and Applied Sciences,State Key Laboratory of Analytical Chemistry for Life Science,Nanjing University,Nanjing 210023,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第8期3780-3782,共3页药学学报（英文版）

基　　金：supported by the National Key Research and Development Program of China(2019YFA0709200);the National Natural Science Foundation of China(21874066);the Key Research and Development Program of Jiangsu Province(BE2021373,China);the Natural Science Foundation of Jiangsu Province(BK20200336,China);the State Key Laboratory of Analytical Chemistry for Life Science(5431ZZXM2304,China);the Program for Innovative Talents and Entrepreneur in Jiangsu(China).

摘　　要：One of the hallmarks of cancer is its inherently immunosuppressive microenvironment,which strategically manipulates surrounding immune cells,signaling molecules,and structural components to shield cancer cells from immune attacks and foster tumor progression1.Such tumor microenvironment is characterized by the presence of immunosuppressive entities such as tumor-associated macrophages,T cells,tumor-associated neutrophils,and myeloid-derived suppressor cells(MDSCs),as well as metabolic alterations like hypoxia2 and elevated lactate levels3.

关 键 词：Immune escape Tumor microenvironment Immunotherapy Immunosuppressive tumor microenvironment Transcription factor CD8^(+)T cell infiltration AKP organoids CRISPReCas9 genome editing 

分 类 号：R730.51[医药卫生—肿瘤]