甲磺酸倍他司汀注射液在改善急性后循环缺血性眩晕患者椎基底动脉血流及调节血清血小板衍生因子和一氧化氮合酶水平中的作用  

Effect of Betahistine mesylate injection on improving vertebrobasilar blood flow and regulating serum platelet-derived growth factor-BB and nitric oxide synthase levels in patients with acute postcirculation ischemic vertigo

作　　者：王磊 程继伟 赵伟峰 Wang Lei;Cheng Jiwei;Zhao Weifeng(不详;Emergency Department,Xinzheng People’s Hospital,Xinzheng 451150,China)

机构地区：[1]新郑市人民医院急诊科,451150 [2]新郑市人民医院重症监护室,451150

出　　处：《国际移植与血液净化杂志》2024年第2期37-40,共4页International Journal of Transplantation and Hemopurification

摘　　要：目的探讨甲磺酸倍他司汀注射液在改善急性后循环缺血性眩晕患者椎基底动脉血流及调节血清血小板衍生因子(platelet-derived growth factor-BB, PDGF-BB)和一氧化氮合酶(nitric oxide synthase, NOS)水平中的作用。方法选取新郑市人民医院急诊科2020年12月至2022年12月期间收治的123例急性后循环缺血性眩晕患者作为研究对象, 对照组61例给予马来酸依那普利叶酸片进行治疗, 观察组62例在对照组的基础上增加甲磺酸倍他司汀注射液治疗。观察两组患者临床疗效、动脉血流速度、血管内皮功能、血管缺血情况及不良反应发生率。结果观察组总有效人数58例, 总有效率为93.55%, 高于对照组总有效人数(49例)和总有效率(80.33%)(P<0.05)。治疗2周后两组患者左椎动脉(left vertebral artery, LVA)、右椎动脉(right vertebral artery, RVA)、基底动脉(basilar artery, BA)的平均血流速度均较治疗前升高, 且观察组高于对照组(P<0.05);治疗2周后两组患者血清降钙素基因相关肽(calcitonin gene-related peptide, CGRP)水平较治疗前升高, 且观察组高于对照组;两组内皮素-1(endothelin-1, ET-1)水平较治疗前降低, 且观察组低于对照组(P<0.05);治疗2周后观察组患者血清PDGF-BB和NOS水平均较治疗前降低, 且观察组低于对照组(P<0.05);治疗期间, 两组患者不良反应发生率差异无统计学意义(P<0.05)。结论甲磺酸倍他司汀注射液治疗急性后循环缺血性眩晕患者可有效提高治疗效果, 改善血流动力学及血管内皮功能和血管缺血情况, 且未增加不良反应, 安全可靠。Objective To investigate the effects of betahistine mesylate injection on improving vertebrobasilar artery flow and regulating serum platelet-derived factor(PDGF-BB)and nitric oxide synthase(NOS)levels in patients with acute postcirculation ischemic vertigo.Methods A total of 123 patients with acute postcirculation ischemic vertigo in Emergency Department,Xinzheng People’s Hospital from December 2020 to December 2022 were selected as the study subjects.Sixty-one patients in the control group were treated with enalapril maleate folic acid tablets,and 62 patients in the observation group were treated with betahistine mesylate injection on the basis of the enalapril maleate folic acid tablets treatment.The clinical efficacy,arterial flow velocity,vascular endothelial function,vascular ischemia and adverse reactions were compared between the two groups.Results The total effective rate in the observation group(58 patients,93.55%)was higher than that in the control group(49 patients,80.33%)(P<0.05).After 2 weeks of treatment,the average blood flow velocity of left vertebral artery(LVA),right vertebral artery(RVA)and basilar artery(BA)in two groups were higher than before treatment,and the observation group was higher than those in the control group(P<0.05).After 2 weeks of treatment,the serum level of calcitonin gene-related peptide(CGRP)in two groups was higher than before treatment,and the observation group was higher than those in the control group.The level of endothelin-1(ET-1)in both groups was lower than before treatment,and the observation group was lower than those in the control group(P<0.05).After 2 weeks of treatment,the levels of PDGF-BB and NOS in the observation group were lower than before treatment,and the observation group was lower than those in the control group(P<0.05).During treatment,there was no significamt difference in the incidence of adverse reactions between the groups(P<0.05).Conclusion Betahistine mesylate injection in the treatment of patients with acute postcirculation ischemic vertig

关 键 词：甲磺酸倍他司汀 急性后循环缺血性眩晕 血管内皮功能 血流动力学 

分 类 号：R743.3[医药卫生—神经病学与精神病学]