Intermittent fasting-a double edged sword for atherosclerosis  

作　　者：Jacques Togo Hoon-Ki Sung 

机构地区：[1]Translational Medicine Program,The Hospital for Sick Children,Toronto,Ontario M5G 0A4,Canada [2]Department of Laboratory Medicine and Pathobiology,University of Toronto,Toronto,Ontario M5S 1A8,Canada

出　　处：《Life Metabolism》2024年第3期9-11,共3页生命代谢（英文）

基　　金：supported by the Canadian Institute of Health Research(CIHR)Fellowship.H.K.S.was supported by the Canadian Institute of Health Research(CIHR,PJT-190016);the Natural Sciences and Engineering Research Council(NSERC,RGPIN-2016-06610)of Canada;the Sun Life Financial New Investigator Award of Banting&Best Diabetes Centre(BBDC)of University of Toronto.

摘　　要：The impact of alternate-day fasting(ADF)on atherosclerosis remains poorly understood,particularly in high-risk populations.In a recent paper published in Life Metabolism,Deng et al.revealed that ADF exacerbated both early and advanced atherosclerotic lesion development in Apoe^(-/-)mice through suppression of hepatic activating transcription factor 3(ATF3)and consequent dysregulation of cholesterol metabolism.

关 键 词：FASTING ATHEROSCLEROSIS 

分 类 号：R543.5[医药卫生—心血管疾病]