肠道菌产生酶与天然药物互作对疾病的影响  

Interactions between gut microbiota-producing enzymes and natural drugs affect disease progression

作　　者：王志宇 申浩然 韩燕星 蒋建东 蒋卫[2] 郭慧慧 WANG Zhi-yu;SHEN Hao-ran;HAN Yan-xing;JIANG Jian-dong;JIANG Wei;GUO Hui-hui(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Zhejiang Zhenyuan Pharmaceutical Co.,Ltd.,Shaoxing 312000,China;Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院、北京协和医学院药物研究所,天然药物活性物质与功能国家重点实验室,北京100050 [2]浙江震元制药有限公司,浙江绍兴312000 [3]中国医学科学院、北京协和医学院医药生物技术研究所,北京100050

出　　处：《药学学报》2024年第8期2183-2191,共9页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(82104254);北京市科技新星计划项目(20230484467);中国医学科学院创新工程重大项目(2021-I2M-1-007)。

摘　　要：天然来源的代谢产物是药物研发的宝贵资源,对疾病的治疗起重要作用。肠道菌群作为机体的“第二基因组”,蕴含丰富的物质代谢酶,可与机体摄入的药物等外来物质相互作用,改变疾病进程。本文总结了肠道菌产生酶与天然药物之间的互作关系,并重点探讨了这种互作关系对疾病的影响,希望能为天然药物的研发及药理机制的探究提供新思路。Naturally derived metabolites are valuable resources for drug research and development,and play an important role in the treatment of diseases.As the"second genome"of the body,gut microbiota is rich in metabolic enzymes,which interacts with external substances such as drugs,thus affecting the progression of diseases.This article summarizes the interaction between gut microbiota-producing enzymes and natural medicines,and focuses on the impact of this interaction on disease progression,hoping to provide new ideas for the development and pharmacological mechanism of natural medicines.

关 键 词：天然药物 肠道菌群 肠道菌产生酶 疾病进程 药物研发 

分 类 号：R966[医药卫生—药理学]