外周血白细胞分化抗原38和IL-22对自身免疫性肝炎患者发生肝硬化的预测效能分析  

Analysis of predictive efficacy of peripheral blood leukocyte differentiation antigen 38 and IL-22 expression in development of cirrhosis in patients with autoimmune hepatitis

作　　者：宋琳 豆鹏产 SONG Lin;DOU Pengchan(Department of Laboratory Medicine,the Third People's Hospital of Chengdu,Chengdu 610000,China;Department of Laboratory and Blood Transfusion,No.987 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army,Baoji 721000,China)

机构地区：[1]成都市第三人民医院检验科,610000 [2]中国人民解放军联勤保障部队第九八七医院检验输血科,陕西宝鸡721000

出　　处：《国际消化病杂志》2024年第4期247-250,269,共5页International Journal of Digestive Diseases

摘　　要：目的 探究外周血白细胞分化抗原38(CD38)和IL-22对自身免疫性肝炎(AIH)患者发生肝硬化的预测效能。方法 选择2019年5月至2022年5月成都市第三人民医院收治的93例AIH患者作为研究对象,根据是否发生肝硬化将患者分为非肝硬化组(n=75)和肝硬化组(n=18)。比较2组的一般资料及血清CD38和IL-22表达水平。采用logistic回归模型分析影响AIH患者发生肝硬化的危险因素。采用ROC曲线分析血清CD38和IL-22对AIH患者发生肝硬化的预测价值。结果 93例AIH患者中肝硬化18例,非肝硬化75例。与非肝硬化组相比,肝硬化组的血清CD38、TBil水平均较高,血清IL-22水平较低,差异均有统计学意义(P均<0.05)。多因素logistic回归模型分析结果显示,血清CD38、TBil和IL-22均是AIH发生肝硬化的独立危险因素(P均<0.05)。ROC曲线分析结果显示,血清CD38和IL-22联合检测预测AIH发生肝硬化的曲线下面积(AUC)为0.849,分别大于单项检测,且联合检测的特异度最高。结论 AIH并发肝硬化患者的血清CD38表达上调,血清IL-22表达下调,两者联合检测对预测AIH患者发生肝硬化具有一定的临床价值。Objective This paper attempts to explore the predictive efficacy of peripheral blood leukocyte differentiation antigen 38(CD38)and IL-22 for the development of cirrhosis in patients with autoimmune hepatitis(AIH).Methods A total of 93 AIH patients admitted to the Third People's Hospital of Chengdu from May 2019 to May 2022 were selected as the research subjects.The patients were divided into the non-cirrhosis group(n=75)and the cirrhosis group(n=18)based on whether they developed cirrhosis,whose general information and serum CD38 and IL-22 expression levels were compared.The logistic regression analysis was conducted to explore the risk factors of cirrhosis.The ROC curve was performed to analyze the predictive value of serum CD38 and IL-22 for the development of cirrhosis.Results Among the 93 AIH patients,there are 18 cases of cirrhosis and 75 cases of non-cirrhosis.Compared with the noncirrhotic group,the serum CD38 and TBil levels in the cirrhotic group are higher,while the IL-22 level is lower,with statistically significant differences(P<0.05).The results of multiple logistic regression model analysis show that serum CD38,TBil,and IL-22 are all independent risk factors for AIH induced cirrhosis(P<0.05).The ROC curve analysis results show that the combined detection of serum CD38 and IL-22 prediction of the area under the curve(AUC)of AIH induced cirrhosis is 0.849,which is larger than that of single detection,and the specificity of the combined detection is the highest.Conclusion The expression of serum CD38 is upregulated and the expression of serum IL-22 is downregulated in patients with AIH complicated with cirrhosis,and the combined detection of both has a certain clinical reference value for predicting the occurrence of cirrhosis in the AIH patients.

关 键 词：自身免疫性肝炎 白细胞分化抗原38 IL-22 肝硬化 

分 类 号：R575[医药卫生—消化系统]